{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:19:46Z","timestamp":1788261586147,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006282","name":"Koning Boudewijnstichting","doi-asserted-by":"publisher","award":["2021"],"award-info":[{"award-number":["2021"]}],"id":[{"id":"10.13039\/501100006282","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the salivary microbiome of patients with laryngopharyngeal reflux disease (LPRD) and investigate its associations with clinical presentation and salivary gastroduodenal enzymes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Saliva samples from patients with LPRD at the 24\u2010hour hypopharyngeal\u2010esophageal multichannel intraluminal impedance\u2010pH testing and asymptomatic individuals were consecutively collected for analyzing digestive enzyme\/biomarker (pepsin, elastase, bile salts, cholesterol, trypsin) and microbiome features (16S rRNA IlluminaMiSeq). Pretreatment to posttreatment symptoms and findings were evaluated with reflux symptom score and reflux sign assessment. Association between microbiome abundance, enzyme concentration, and baseline and post\u2010treatment clinical findings were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010seven LPRD patients (40 females [59.7%]) and 44 controls (26 females [59.1%]) completed the evaluations. LPRD patients demonstrated significantly higher concentrations of elastase, higher salivary pH, and lower levels of cholesterol compared to controls. The comparative analysis of salivary microbiota between LPRD patients and controls demonstrated significant taxonomic\u2010level alterations in alpha diversity (reduced Shannon index at family and genus levels in LPRD,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.006) and beta diversity (distinct community composition by UniFrac metrics, PERMANOVA,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u2009.005), with differential abundance of key taxa including a modulation of\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      species, elevated\n                      <jats:italic>Actinomyces<\/jats:italic>\n                      and\n                      <jats:italic>Abiotrophia<\/jats:italic>\n                      , and depleted\n                      <jats:italic>Oribacterium<\/jats:italic>\n                      and\n                      <jats:italic>Eubacterium nodatum<\/jats:italic>\n                      group in LPRD patients compared to controls. Elastase, trypsin, and bile salts reported significant association with relative abundance of some bacteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This preliminary study supports that LPRD patients exhibit distinct microbial signatures compared to asymptomatic subjects, characterized by reduced diversity at specific taxonomic levels, subtle shifts in community membership, and differential abundance of some key genera<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70421","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:03:40Z","timestamp":1788260620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laryngopharyngeal Reflux Disease: Microbial Signatures and Their Associations With Clinical and Digestive Enzyme Profiles"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Surgery, UMONS Research Institute for Health Sciences and Technology University of Mons Mons Belgium"},{"name":"Department of Surgery, UMONS Research Institute for Health Sciences and Technology University of Mons Mons France"},{"name":"Department of Otolaryngology Elsan Polyclinic de l'Atlantique Poitiers France"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia B.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Metabolism and Nutrition Research Group Louvain Drug Research Institute (LDRI), UCLouvain Brussels Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO) Department WEL Research Institute Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie De","family":"Vos","sequence":"additional","affiliation":[{"name":"Laboratoire Hospitalier Universitaire Bruxelles\u2013Universitair Laboratorium Brussel (LHUB\u2010ULB), Department of Laboratory Medicine CHU Saint\u2010Pierre, Free University of Brussels Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Trelcat","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMONS Research Institute for Health Sciences and Technology University of Mons Mons Belgium"},{"name":"Metabolism and Nutrition Research Group Louvain Drug Research Institute (LDRI), UCLouvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinciane","family":"Muls","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Aoun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dequanter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Surgery, UMONS Research Institute for Health Sciences and Technology University of Mons Mons France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Briganti","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine and Neuropsychiatry, Faculty of Medicine University of Mons Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Everard","sequence":"additional","affiliation":[{"name":"Metabolism and Nutrition Research Group Louvain Drug Research Institute (LDRI), UCLouvain Brussels Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO) Department WEL Research Institute Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"},{"name":"Department of Anatomy and Experimental Oncology, UMONS Research Institute for Health Sciences and Technology University of Mons Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1080\/07853890.2022.2074535","article-title":"Global, regional and national burden of gastroesophageal reflux disease, 1990\u20102019: update from the GBD 2019 study","volume":"54","author":"Zhang D","year":"2022","journal-title":"Ann Med"},{"key":"e_1_2_9_3_1","article-title":"The San Diego consensus for laryngopharyngeal symptoms and laryngopharyngeal reflux disease","author":"Yadlapati R","year":"2025","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.cgh.2019.09.029","article-title":"Laryngopharyngeal reflux is an eternally rolling boulder","volume":"18","author":"Yadlapati R","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ajg.2013.69","article-title":"High economic burden of caring for patients with suspected extraesophageal reflux","volume":"108","author":"Francis DO","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00405-024-08881-w","article-title":"Cost burden for healthcare and patients related to the unawareness towards laryngopharyngeal reflux","volume":"283","author":"Lechien JR","year":"2026","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ajg.2011.286","article-title":"Mechanisms of reflux perception in gastroesophageal reflux disease: a review","volume":"107","author":"Bredenoord AJ","year":"2012","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/lary.31134","article-title":"The Dubai definition and diagnostic criteria of laryngopharyngeal reflux: the IFOS consensus","volume":"134","author":"Lechien JR","year":"2024","journal-title":"Laryngoscope"},{"issue":"10","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s00405-020-05969-x","article-title":"Study on laryngopharyngeal and esophageal reflux characteristics using 24\u2010h multichannel intraluminal impedance\u2010pH monitoring in healthy volunteers","volume":"277","author":"Hou C","year":"2020","journal-title":"Eur Arch Otrhinolaryngol"},{"issue":"2","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/lary.70062","article-title":"Accuracy and clinical findings of saliva digestive biomarkers in laryngopharyngeal reflux disease","volume":"136","author":"Lechien JR","year":"2026","journal-title":"Laryngoscope"},{"issue":"2","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jvoice.2021.09.023","article-title":"Impact of acid, weakly acid and alkaline laryngopharyngeal reflux on voice quality","volume":"38","author":"Lechien JR","year":"2024","journal-title":"J Voice"},{"issue":"4","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/MOG.0000000000001108","article-title":"Update on laryngopharyngeal reflux disease","volume":"41","author":"Algara MA","year":"2025","journal-title":"Curr Opin Gastroenterol"},{"issue":"3","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.otc.2024.12.001","article-title":"Diagnostic testing for laryngopharyngeal reflux disease: the role of 24\u2010hour hypopharyngeal\u2010esophageal multichannel intraluminal impedance\u2010pH monitoring","volume":"58","author":"Aoun J","year":"2025","journal-title":"Otolaryngol Clin North Am"},{"issue":"10","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1002\/lary.31453","article-title":"Microbial composition of the laryngotracheal region: a systematic review","volume":"134","author":"Sragi Z","year":"2024","journal-title":"Laryngoscope"},{"issue":"3","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.otc.2024.09.006","article-title":"Microbiota, gut health, and laryngopharyngeal reflux disease","volume":"58","author":"Lee JG","year":"2025","journal-title":"Otolaryngol Clin North Am"},{"issue":"5","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1177\/01945998211029831","article-title":"Normative ambulatory reflux monitoring metrics for laryngopharyngeal reflux: a systematic review of 720 healthy individuals","volume":"166","author":"Lechien JR","year":"2022","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"E98","DOI":"10.1002\/lary.28017","article-title":"Validity and reliability of the reflux symptom score","volume":"130","author":"Lechien JR","year":"2020","journal-title":"Laryngoscope"},{"issue":"4","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/0003489419888947","article-title":"Validity and reliability of the reflux sign assessment","volume":"129","author":"Lechien JR","year":"2020","journal-title":"Ann Otol, Rhinol, Laryngol"},{"issue":"2","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/gutjnl-2023-330616","article-title":"Updates to the modern diagnosis of GERD: Lyon consensus 2.0","volume":"73","author":"Gyawali CP","year":"2024","journal-title":"Gut"},{"issue":"5","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/ohn.674","article-title":"Digestive biomarkers of laryngopharyngeal reflux: a preliminary prospective controlled study","volume":"170","author":"Lechien JR","year":"2024","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen E","year":"2019","journal-title":"Nat Biotechnol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high\u2010resolution sample inference from Illumina amplicon data","volume":"137","author":"Callahan BJ","year":"2016","journal-title":"Nat Methods"},{"issue":"1","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","article-title":"Optimizing taxonomic classification of marker\u2010gene amplicon sequences with QIIME 2's q2\u2010feature\u2010classifier plugin","volume":"6","author":"Bokulich NA","year":"2018","journal-title":"Microbiome"},{"issue":"11","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009581","article-title":"RESCRIPt: reproducible sequence taxonomy reference database management","volume":"17","author":"Robeson MS","year":"2021","journal-title":"PLoS Comput Biol"},{"issue":"12","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1007\/s00405-019-05631-1","article-title":"Development of scores assessing the refluxogenic potential of diet of patients with laryngopharyngeal reflux","volume":"276","author":"Lechien JR","year":"2019","journal-title":"Eur Arch Otrhinolaryngol"},{"issue":"11","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009442","article-title":"Multivariable association discovery in population\u2010scale meta\u2010omics studies","volume":"17","author":"Mallick H","year":"2021","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1186\/s12903-024-05000-3","article-title":"Salivary microbiota composition before and after use of proton pump inhibitors in patients with laryngopharyngeal reflux: a self\u2010control study","volume":"24","author":"Cui X","year":"2024","journal-title":"BMC Oral Health"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.110460","article-title":"Laryngopharyngeal reflux: the microbiota theory","volume":"146","author":"Lechien JR","year":"2021","journal-title":"Med Hypotheses"},{"issue":"1","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.36740\/WLek202301108","article-title":"Specific features of the oral microbiome in young children with aryngopharyngeal reflux and its role the development of recurrent respiratory diseases","volume":"76","author":"Mozheiko TV","year":"2023","journal-title":"Wiadomo\u015bci Lekarskie"},{"issue":"4","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.job.2023.08.005","article-title":"Alterations of the salivary microbiota in gastroesophageal reflux disease","volume":"65","author":"Qian J","year":"2023","journal-title":"J Oral Biosci"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2681791","article-title":"Comparison of the microbiota and inorganic anion content in the saliva of patients with gastroesophageal reflux disease and gastroesophageal reflux disease\u2010free individuals","volume":"2020","author":"Ziganshina EE","year":"2020","journal-title":"BioMed Res Int"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.732613","article-title":"Effects of Helicobacter pylori infection on the oral microbiota of reflux esophagitis patients","volume":"11","author":"Liang T","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"10","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/ijc.34191","article-title":"Progressive dysbiosis of human orodigestive microbiota along the sequence of gastroesophageal reflux, Barrett's esophagus and esophageal adenocarcinoma","volume":"151","author":"Hao Y","year":"2022","journal-title":"Int J Cancer"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01000","article-title":"Patients with reflux esophagitis Possess a Possible Different Oral Microbiota Compared With Healthy Controls","volume":"11","author":"Wang B","year":"2020","journal-title":"Front Pharmacol"},{"issue":"8","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"E479","DOI":"10.1002\/lary.28482","article-title":"Gastroesophageal reflux in laryngopharyngeal reflux patients: Clinical features and therapeutic response","volume":"130","author":"Lechien JR","year":"2020","journal-title":"Laryngoscope"},{"issue":"6","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bjorl.2023.101331","article-title":"Analysis on the pharyngeal microbiota in patients with laryngopharyngealreflux disease","volume":"89","author":"Zhang J","year":"2023","journal-title":"Braz J Otorhinolaryngol"},{"issue":"7","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1007\/s00405-022-07327-5","article-title":"Distinct microbiota dysbiosis in patients with laryngopharynx reflux disease compared to healthy controls","volume":"279","author":"Chen H","year":"2022","journal-title":"Eur Arch Otrhinolaryngol"},{"issue":"4","key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00405-013-2682-y","article-title":"Factors confusing the diagnosis of laryngopharyngeal reflux: the role of allergic rhinitis and inter\u2010rater variability of laryngeal findings","volume":"271","author":"Eren E","year":"2014","journal-title":"Eur Arch Otrhinolaryngol"},{"issue":"4","key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/coa.14047","article-title":"Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: a systematic review","volume":"48","author":"Lechien JR","year":"2023","journal-title":"Clin Otolaryngol"},{"issue":"21","key":"e_1_2_9_40_1","first-page":"00420","article-title":"Prevalence of laryngopharyngeal reflux related symptoms in patients with allergy","volume":"0892","author":"Hamdan AL","year":"2022","journal-title":"J Voice"},{"issue":"25","key":"e_1_2_9_41_1","article-title":"Influence of inhaled corticosteroids on voice quality: a systematic review","volume":"0892","author":"Lechien JR","year":"2025","journal-title":"J Voice"},{"issue":"2","key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/0145561319881559","article-title":"Smoking cessation improves the symptoms and the findings of laryngeal irritation","volume":"99","author":"Kayal\u0131 Dinc AS","year":"2020","journal-title":"Ear Nose Throat J"},{"issue":"6","key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1111\/all.15268","article-title":"Variations in oral microbiota and salivary proteomics reveal distinct patterns in polysensitized individuals","volume":"77","author":"Wang Y","year":"2022","journal-title":"Allergy"},{"issue":"1","key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.31557\/APJCP.2025.26.1.309","article-title":"The impact of electronic and conventional cigarette use towards saliva profile and oral microbiota in adolescents","volume":"26","author":"Kurniawan A","year":"2025","journal-title":"Asian Pac J Cancer Prev"},{"issue":"4","key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.aller.2011.04.005","article-title":"Assessing caries, dental plaque and salivary flow in asthmatic adolescents using inhaled corticosteroids","volume":"40","author":"Santos NC","year":"2012","journal-title":"Allergol Immunopathol"},{"issue":"16","key":"e_1_2_9_46_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26168104","article-title":"Identification of non\u2010invasive diagnostic markers for oral squamous cell carcinoma through salivary microbiome and gene expression analysis","volume":"26","author":"Hishida M","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"25","key":"e_1_2_9_47_1","first-page":"00083","article-title":"Dysbiosis Patterns in glottic and laryngeal cancers: a systematic review of microbiome alterations","volume":"0892","author":"Lechien JR","year":"2025","journal-title":"J Voice"},{"issue":"1","key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/prd.12098","article-title":"Influence of saliva on the oral microbiota","volume":"70","author":"Marsh PD","year":"2016","journal-title":"Periodontol 2000"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70421","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70421","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:03:46Z","timestamp":1788260626000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":47,"alternative-id":["10.1002\/ohn.70421"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70421","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ohn.70421"}}