{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T15:04:03Z","timestamp":1789311843556,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the efficacy of a prophylactic, home\u2010based exercise program administered concomitantly with radiotherapy in patients with head and neck cancer to preserve swallowing function, postural alignment, and cervical range of motion, while assessing lymphedema safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Outpatient clinics of an academic university hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four patients undergoing radiotherapy for head and neck cancer were allocated to an exercise group (n\u2009=\u200912; receiving a swallowing, posture, range of motion, and strengthening protocol) or a control group (n\u2009=\u200912; receiving standard care). Baseline and postradiotherapy outcomes were assessed using the Swallowing Quality of Life questionnaire, photogrammetric posture analysis, digital goniometry for cervical mobility, and circumference measurements for lymphedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Swallowing Quality of Life was maintained in the exercise group but deteriorated significantly in controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The exercise group significantly preserved neck lateral tilt compared to controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Furthermore, the intervention group demonstrated significant preservation of cervical flexion, extension, rotation, and lateral flexion (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Facial edema metrics increased slightly in both groups with no significant inter\u2010group differences, confirming intervention safety (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05). High adherence rates were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A prophylactic, home\u2010based exercise program is a safe and effective strategy to mitigate functional decline in patients undergoing radiotherapy. The intervention preserves swallowing, posture, and cervical mobility without exacerbating lymphedema, supporting early prehabilitation in oncological care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT07376213.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70442","type":"journal-article","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T14:18:21Z","timestamp":1789309101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prophylactic Home\u2010Based Exercises During Radiotherapy in Head and Neck Cancer: A Randomized Controlled Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-5479","authenticated-orcid":false,"given":"Burak","family":"Erturk","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences Karadeniz Technical University Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5641-2915","authenticated-orcid":false,"given":"Mehmet","family":"D\u00fczl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-8157","authenticated-orcid":false,"given":"\u00d6zge P.","family":"Erpolat","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6999-4056","authenticated-orcid":false,"given":"\u0130lke","family":"Keser","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/10833196.2025.2508117","article-title":"Cancer treatment\u2010related head and neck fibrosis: a narrative perspective of epidemiology, pathophysiology, prevention, assessment and non\u2010surgical treatment","volume":"30","author":"Morrissey MC","year":"2025","journal-title":"Phys Ther Rev"},{"issue":"2","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s40141-023-00394-7","article-title":"Neuromuscular complications of radiation fibrosis syndrome","volume":"11","author":"Lee H","year":"2023","journal-title":"Curr Phys Med Rehab Rep"},{"issue":"3","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/lary.28880","article-title":"Cervical fibrosis as a predictor of dysphagia","volume":"131","author":"Nachalon Y","year":"2021","journal-title":"Laryngoscope"},{"key":"e_1_2_8_5_1","first-page":"150982","volume-title":"Clinical Evaluation and Management of Cancer Survivors With Radiation Fibrosis Syndrome","author":"DiFrancesco T","year":"2020"},{"issue":"11","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.pmrj.2011.08.535","article-title":"Radiation fibrosis syndrome: neuromuscular and musculoskeletal complications in cancer survivors","volume":"3","author":"Stubblefield MD","year":"2011","journal-title":"PM & R"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"83","article-title":"Prehabilitation in radiation therapy: a scoping review","volume":"32","author":"Flores LE","year":"2024","journal-title":"Supp Care Cancer"},{"issue":"1","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"8523","DOI":"10.1038\/s41598-023-35503-y","article-title":"Exercise\u2010based rehabilitation on functionality and quality of life in head and neck cancer survivors. 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