{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T15:04:13Z","timestamp":1789311853792,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the prognostic performance of a discrete\u2010time pooled logistic regression (PLR) model and a continuous\u2010time Cox proportional hazards (Cox) model for predicting 2\u2010, 5\u2010, 10\u2010, and 15\u2010year recurrence risk after endoscopic sinus surgery (ESS) in chronic rhinosinusitis (CRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single tertiary academic center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 543 CRS patients who underwent ESS were included for analysis of time to recurrence. Ten predictors, including age, sex, smoking status, asthma, NSAID hypersensitivity, symptom duration, blood eosinophil count (BEC), nasal polyp score (NPS), MLK Discharge\u2010Edema subscore (MLK\u2010DE subscore), and Lund\u2010Mackay (LM) score, were evaluated using LASSO\u2010penalized PLR and Cox models. Nomogram performance was assessed using time\u2010dependent AUROC, Brier scores, calibration, 1000\u2010bootstrap internal validation, and decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recurrence occurred in 46.8%. LASSO identified age, NSAID hypersensitivity, asthma, symptom duration, BEC, NPS, MLK\u2010DE subscore, and LM score as key predictors, with smoking status retained only in PLR model. PLR model demonstrated numerically higher discrimination (AUROCs 0.899\u20100.912 vs 0.879\u20100.899) with similar Brier scores (0.111\u20100.144 vs 0.128\u20100.142). PLR calibration remained strong over time, whereas Cox calibration declined over longer follow\u2010up. Although Cox performed slightly better at early time points, PLR demonstrated consistent discrimination during internal validation (AUROCs 0.863\u20100.892 vs 0.876\u20100.897). DCA showed greater and stable net benefit for PLR across all time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both models performed well in predicting long\u2010term recurrence, but the LASSO\u2010penalized PLR nomogram provided numerically higher and more consistent discrimination, calibration, and clinical utility over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70447","type":"journal-article","created":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T14:17:38Z","timestamp":1789309058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Long\u2010Term Recurrence Prediction in Chronic Rhinosinusitis Following Endoscopic Sinus Surgery Using a Discrete\u2010Time Model"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-8975","authenticated-orcid":false,"given":"Virat","family":"Kirtsreesakul","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Prince of Songkla University  Hat Yai, Songkhla 90110 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-7988","authenticated-orcid":false,"given":"Paramee","family":"Thongsuksai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Prince of Songkla University  Hat Yai, Songkhla 90110 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-4988","authenticated-orcid":false,"given":"Nuttha","family":"Sanghan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Prince of Songkla University  Hat Yai, Songkhla 90110 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-7789","authenticated-orcid":false,"given":"Chakapan","family":"Promsopa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Prince of Songkla University  Hat Yai, Songkhla 90110 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"issue":"29","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.600","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinol J"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/alr.22741","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis 2021","volume":"11","author":"Orlandi 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