{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:13:34Z","timestamp":1790241214102,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the therapeutic response patterns in terms of duration, resistance, and therapeutic failure in patients with a confirmed LPRD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with laryngopharyngeal symptoms and &gt;1 pharyngeal reflux event on 24\u2010h hypopharyngeal\u2010esophageal impedance\u2010pH monitoring were prospectively recruited (European Reflux Clinic, Jan 2017\u2010Oct 2025). Based on LPRD pattern, they received diet\/lifestyle measures plus alginate, magaldrate and\/or PPIs in successive 3\u2010month courses until significant symptom relief allowed discontinuation. Outcomes (RSS, RSA) and optimal treatment duration, success\/weaning rates, and chronicity were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 361 consecutive patients completed the evaluations (214 females, 59.3%), with 135 (37.4%), 87 (24.1%), and 139 (38.5%) presenting mild, moderate, and severe reflux disease (IFOS classification), respectively. Of 304 patients with complete follow\u2010up, 105 (34.5%) achieved complete response, occurring primarily at 6 weeks (27.6%), 3 months (42.9%), and 6 months (21.9%) posttreatment; 93\/105 (88.6%) remained symptom\u2010free after discontinuation. Symptoms stabilized in 148\/304 (48.7%) patients continuing diet and lifestyle modifications with\/without medication. Fluctuating relief and chronic course occurred in 21\/304 (6.9%) and 30\/304 (9.9%) despite drug class changes. Binary logistic regression revealed baseline IFOS classification as a significant predictor of complete response (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.038, OR\u2009=\u20091.518, 95% CI [1.024\u20102.251]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several LPRD patterns were identified: 34.5% achieved complete remission, 48.7% showed sustained symptom reduction, and 16.8% had fluctuating\/chronic symptoms despite drug class changes. Baseline IFOS score predicts therapeutic trajectory and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70453","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:56:06Z","timestamp":1790240166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Duration and Clinical Response Patterns of Laryngopharyngeal Reflux Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Surgery UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons) Mons Belgium"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital, Paris Saclay University Paris France"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Elsan Hospital Paris 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