{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:58:43Z","timestamp":1790344723931,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study is to evaluate the pooled diagnostic performance of cervical (cVEMP) and ocular (oVEMP) vestibular\u2010evoked myogenic potentials for Acute Unilateral Vestibulopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE, Scopus, and Cochrane Central were searched for relevant articles from inception to October 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>We included prospective, retrospective, and cross\u2010sectional studies evaluating the performance of cVEMP and oVEMP for the diagnosis of acute unilateral vestibulopathy in adult patients. The pooled estimates of the sensitivity and specificity of cVEMP and oVEMP in the diagnosis of acute unilateral vestibulopathy were calculated using a random\u2010effects analysis that accounts for heterogeneity if present. Forest plots were constructed to combine the evidence identified during the systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one studies were included; 15 contributed to diagnostic accuracy meta\u2010analyses (519 patients, 577 controls). Pooled cVEMP sensitivity was 40% (95% CI, 0.30\u20100.50;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200964.2%) and specificity 100% (95% CI, 0.00\u20101.00;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Pooled oVEMP sensitivity was 74% (95% CI, 0.57\u20100.86;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200955.9%) and specificity 99% (95% CI, 0.88\u20101.00;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Abnormality rates were 40% for cVEMP (633\/1540;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200985.2%) and 67% for oVEMP (679\/1135;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200992.7%). Subgroup analyses revealed enhanced oVEMP sensitivity with air\u2010conducted sound (76%) and tone\u2010burst stimuli (82%), while cVEMP achieved superior sensitivity when elicited by bone\u2010conducted vibration (49% vs 37% with air\u2010conducted sound).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VEMPs show high specificity but moderate sensitivity for diagnosing acute unilateral vestibulopathy, with oVEMP outperforming cVEMP because superior vestibular nerve involvement is more common. Therefore, VEMPs should be used as complementary rather than standalone tests alongside clinical and canal\u2010based tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70457","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:59:57Z","timestamp":1790341197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Performance of Vestibular\u2010Evoked Myogenic Potentials for Acute Unilateral Vestibulopathy: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","author":[{"given":"Mikhael","family":"Makhoul","sequence":"first","affiliation":[{"name":"Service d'ORL, Otoneurologie et ORL p\u00e9diatrique, CHU Toulouse Purpan Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Ismail","sequence":"additional","affiliation":[{"name":"Service d'ORL, Otoneurologie et ORL p\u00e9diatrique, CHU Toulouse Purpan Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dima","family":"Tawk","sequence":"additional","affiliation":[{"name":"Service d'ORL, H\u00f4tel Dieu de France, Boulevard Alfred Naccache Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialida","family":"Farah","sequence":"additional","affiliation":[{"name":"Service d'ORL, H\u00f4tel Dieu de France, Boulevard Alfred Naccache Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Khneisser","sequence":"additional","affiliation":[{"name":"Service d'ORL, H\u00f4tel Dieu de France, Boulevard Alfred Naccache Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Rassam","sequence":"additional","affiliation":[{"name":"Service d'ORL, H\u00f4tel Dieu de France, Boulevard Alfred Naccache Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Legois","sequence":"additional","affiliation":[{"name":"Service d'ORL, Otoneurologie et ORL p\u00e9diatrique, CHU Toulouse Purpan Toulouse France"},{"name":"Unit\u00e9 Mixte de Recherche UMR5549, CNRS, Centre de Recherche Cerveau et Cognition Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3402739"},{"issue":"10","key":"e_1_2_10_3_1","article-title":"Is vestibular neuropathy rather a neuritis?","volume":"14","author":"Haeussler SM","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000175987.59991.3d"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.03.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-220201"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-021-06094-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/459048"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890200035008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.11.042"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.09.027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2021.01.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-019-00767-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-025-07079-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.14.9.5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2019.01.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_10_19_1","unstructured":"R: The R Project for Statistical Computing.R: A Language and Environment for Statistical Computing. 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