{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:48:14Z","timestamp":1792000094724,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine the risk of a new\u2010encounter diagnosis of unspecified chronic rhinosinusitis (CRS), CRS with nasal polyps (CRSwNP), and eosinophilic granulomatosis with polyangiitis (EGPA) 1 and 2 years following body mass index (BMI) classification of obesity utilizing a large\u2010population\u2010based analytics platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort analysis<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The U.S. Collaborative Network within the TriNetX Analytics platform contains deidentified electronic health record (EHR) data of more than 100 million patients and was used to determine the association between obesity and a new encounter diagnosis of 3 CRS phenotypes in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1:1 propensity score matching, patients with an overweight BMI and obesity were at a higher risk for a new\u2010encounter diagnosis of unspecified CRS and CRSwNP compared to healthy\u2010weight individuals. The obesity cohort had the greatest increased risk of new\u2010onset unspecified CRS with a relative risk of 1.23 (95% CI: 1.20\u20101.25) and 1.26 (95% CI: 1.24\u20101.28) 1 and 2 years following BMI classification, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates an association between obesity and new\u2010onset unspecified CRS and CRSwNP. With the increasing prevalence of obesity in the United States population, it will be important to understand how obesity\u2010associated CRS may affect treatment response. Future prospective studies are needed to assess causality and define a mechanistic link.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.716","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T07:37:04Z","timestamp":1710401824000},"page":"269-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Obesity is Associated with Increased Risk of New\u2010Onset Chronic Rhinosinusitis: A United States Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"171","author":[{"given":"David","family":"Hoying","sequence":"first","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Kaelber","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA"},{"name":"The Center for Clinical Informatics Research and Education, The MetroHealth System Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad R.","family":"Chaaban","sequence":"additional","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Obesity is a Common Serious and Costly Disease. Centers for Disease Control and Prevention. Accessed August 7 2023.https:\/\/www.cdc.gov\/obesity\/data\/adult.html"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1919-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.050"},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","unstructured":"quiz 910.doi:10.1016\/j.jaci.2004.11.050","DOI":"10.1016\/j.jaci.2004.11.050"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2003.1419"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.4.1256"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/12.3.166"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.3.191"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.11.2004235"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.5.396"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020169"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165887"},{"key":"e_1_2_8_14_1","unstructured":"Adult chronic rhinosinusitis | Nature Reviews Disease Primers. Accessed May 7 2023.https:\/\/www.nature.com\/articles\/s41572-020-00218-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24581"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12759"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2015.8.3.194"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32195"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4096845"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047230"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07320-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150134"},{"key":"e_1_2_8_24_1","unstructured":"CDC. Defining Adult Overweight and Obesity. Centers for Disease Control and Prevention. Accessed August 25 2023.https:\/\/www.cdc.gov\/obesity\/basics\/adult-defining.html"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.12.10"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3142"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.004"},{"key":"e_1_2_8_28_2","doi-asserted-by":"crossref","unstructured":"quiz708\u2010709.doi:10.1016\/j.jaci.2011.08.004","DOI":"10.1016\/j.jaci.2011.08.004"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2017.31.4445"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11010026"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00718-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.612"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31373-6"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036631"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21599"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4182"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:35:50Z","timestamp":1760967350000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ohn.716"],"URL":"https:\/\/doi.org\/10.1002\/ohn.716","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"2023-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}