{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:08:43Z","timestamp":1784819323242,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the value of carbon dioxide transoral laser microsurgery (CO<jats:sub>2<\/jats:sub> TOLMS) for early\u2010stage glottic cancer with special regard to involvement of the anterior commissure (AC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Single\u2010center retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Grade\u2010A tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of patients with early\u2010stage (Tis\u2010T2) glottic cancer who underwent CO<jats:sub>2<\/jats:sub> TOLMS. All patients had at least 2 years of follow\u2010up. The univariate and multivariate survival analyses were used to identify the risk factors for recurrence and the Kaplan\u2010Meier method was used to analyze OS and DSS rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 102 patients were included in the study. Eleven patients (10.78%) had recurrence. The univariate analysis showed that the recurrence was associated with the AC classification, T staging, tumor size, and tobacco use (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). However, on multivariate analysis, the AC classification was the only independent risk factor for recurrence (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, HR\u2009=\u20093.179). AC classification were distributed as follows: 59 (57.84%) AC0, 29 (28.43%) AC1, 8 (7.84%) AC2, and 6 (5.88%) AC3, 2\u2010year\/5\u2010year OS and DSS rates were progressively reduced in the AC0, AC1, AC2, and AC3 groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). At the same T staging, the OS rates incrementally decreased as the level of involvement of the AC became higher (<jats:italic>P<\/jats:italic>\u2009=\u2009.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CO<jats:sub>2<\/jats:sub> TOLMS is an effective treatment for early\u2010stage glottic cancer. AC involvement is an independent risk factors for recurrence and poor prognosis. The AC classification system may be better at grading the prognosis of patients with early\u2010stage glottic cancer and has prognostic value independent of T staging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.767","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T06:43:12Z","timestamp":1713508992000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oncological Outcomes of Transoral Laser Microsurgery for Early Stage Glottic Cancer with Involvement of the Anterior Commissure"],"prefix":"10.1002","volume":"171","author":[{"given":"Di","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Second Hospital of Jilin University Changchun Jilin Province People's Republic of 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of Otolaryngology\u2013Head and Neck Surgery The Second Hospital of Jilin University Changchun Jilin Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuanjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Second Hospital of Jilin University Changchun Jilin Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Second Hospital of Jilin University Changchun Jilin Province People's Republic of 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