{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:41:00Z","timestamp":1760960460111,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hypoparathyroidism and associated hypocalcemia are well\u2010established complications following laryngectomy. This study further characterizes the rates of hypocalcemia in patients undergoing total laryngectomy (TL) with and without thyroidectomy and hemithyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>TriNetX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried TriNetX, a deidentified patient database, to identify patients who underwent TL with and without thyroidectomy and hemithyroidectomy. Rates of hypocalcemia, low parathyroid hormone (PTH), calcium, and calcitriol supplementation were compared between groups with multivariable repeated measures logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 870 patients in the TL without thyroidectomy cohort, 158 patients in the hemithyroidectomy cohort, and 123 in the total thyroidectomy cohort. Rates of hypocalcemia differed between patients receiving total thyroidectomy versus TL alone for 0 to 1 month (odds ratio [OR]: 2.88 [1.95\u20104.26]) 1 to 6 months (OR: 5.08 [2.29\u201011.3]), and 6 to 12 months (OR: 2.63 [1.003\u20106.88]) postoperatively, with adjustment for age at laryngectomy, race, ethnicity, and gender. Results were similar among those who received calcium supplementation. The rate of low PTH levels differed in these groups for 0 to 1 month (OR: 5.13 [3.10\u20108.51]), 1 to 6 months (OR: 3.47 [1.46\u20108.22]), and 6 to 12 months (OR: 3.63 [1.40\u20109.38]) following surgery. Rates of postoperative calcium supplementation were increased for patients receiving total thyroidectomy versus TL for 1 to 6 months (OR: 2.44 [1.62\u20103.68]), and 6 to 12 months following surgery (OR: 1.79 [1.18\u20102.72]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients undergoing TL with total thyroidectomy have a higher risk of postoperative hypocalcemia compared to patients receiving TL alone. Risk of parathyroid injury in these patients may warrant further emphasis on PTH measurement after surgery and a multidisciplinary approach to management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.804","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:59:20Z","timestamp":1715590760000},"page":"685-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Hypocalcemia Following Total Laryngectomy With and Without Thyroidectomy"],"prefix":"10.1002","volume":"171","author":[{"given":"H\u00e4nel W.","family":"Eberly","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Penn State Milton S. Hershey Medical Center and Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao Y.","family":"Sciscent","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Penn State Milton S. Hershey Medical Center and Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Jeffrey Lorenz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Penn State Milton S. Hershey Medical Center and Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Penn State Milton S. 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Hershey Medical Center and Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1981.tb01810.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24429"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100142458"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198510000-00006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06213-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03234-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.614089"},{"issue":"3","key":"e_1_2_8_9_1","first-page":"144","article-title":"Identification of patients at high risk for hypocalcemia after total thyroidectomy","volume":"31","author":"Tredici P","year":"2011","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0803050"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103316"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39582.589433.BE"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.07.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/954194"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118001615"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.17.00067"},{"volume-title":"Up\u2010 to Date","year":"2021","author":"Goltzman D","key":"e_1_2_8_17_1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014455"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3909"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4105-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.11.035"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0348-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2017.0194"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000402"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.3619"},{"key":"e_1_2_8_26_1","unstructured":"Otolaryngology coding alert. 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