{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:11:00Z","timestamp":1792134660559,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of wait and scan (W&amp;S) and stereotactic radiosurgery (SRS) on health\u2010related quality of life (HRQoL) over time in patients with a stable vestibular schwannoma (VS) and growing VS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Longitudinal, multicenter, observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary expert center for VS (Radboudumc Nijmegen) and Gamma\u2010Knife center ETZ Hospital Tilburg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Changes in HRQoL, measured with the Penn Acoustic Neuroma Quality\u2010of\u2010Life (PANQOL), and the physical and mental component summary scores (PCS and MCS, respectively) derived from the\u00a036\u2010Item Short Form Health Survey\u00a0(SF\u201036), were compared among patients managed by W&amp;S and SRS between 2017 and 2022. Second, HRQoL over time in patients with a growing VS was compared between W&amp;S and SRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differences in PANQOL total and subdomain scores, PCS and MCS scores over time in the W&amp;S (n\u2009=\u200973) and SRS (n\u2009=\u2009170) groups were nonsignificant and on average did not exceed the minimal clinically important differences (mean difference of \u22122.56 [PANQOL total], 1.22 [PCS], and \u22121.76 [MCS]; all <jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). In growing VS, comparison of W&amp;S (n\u2009=\u200929) and SRS (n\u2009=\u2009154) also revealed no significant difference (mean difference of 1.19 (PANQOL total), 1.83 (PCS) and \u22120.12 (MCS); all <jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Differences in HRQoL in patients with VS are minor and not significantly different or clinically relevant between patients managed with W&amp;S or SRS. Similarly, patients with a growing VS managed with W&amp;S or SRS exhibit no significant or clinical relevant difference in HRQoL during follow\u2010up. This can aid clinicians in the counseling of patients regarding HRQoL when deciding on a management strategy after diagnosis or documented growth.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.814","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T02:48:44Z","timestamp":1716259724000},"page":"823-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Health\u2010Related Quality of Life in Patients With a Stable or Growing Vestibular Schwannoma Managed by Wait and Scan or Stereotactic Radiosurgery"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-5626","authenticated-orcid":false,"given":"Ineke M.J.","family":"Pruijn","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Radboud Institute for Health Sciences, Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Dutch Academic Alliance Skull Base Pathology Radboud University Medical Center, Maastricht University Medical Center+ Nijmegen\/Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Parmaksiz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Radboud Institute for Health Sciences, Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen B.","family":"Verheul","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Gamma Knife Center, ETZ Hospital Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jef J.S.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Radboud Institute for Health Sciences, Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Dutch Academic Alliance Skull Base Pathology Radboud University Medical Center, Maastricht University Medical Center+ Nijmegen\/Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wietske","family":"Kievit","sequence":"additional","affiliation":[{"name":"Department of Health Evidence Radboud Institute for Health Sciences, Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henricus P.M.","family":"Kunst","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Radboud Institute for Health Sciences, Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Dutch Academic Alliance Skull Base Pathology Radboud University Medical Center, Maastricht University Medical Center+ Nijmegen\/Maastricht The Netherlands"},{"name":"Department of Otorhinolaryngology Maastricht University Medical Center Maastricht The 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