{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:27:53Z","timestamp":1761006473636,"version":"build-2065373602"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Whether ligation or reconstruction should be performed after radical resection of the tumor and carotid artery in patients with head and neck cancers invading the carotid artery (HNC\u2010CA) has been controversial. This paper provides a review and meta\u2010analysis of the efficacy of these 2\u00a0modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, Cochrane, Web of Science, Scopus, and Ovid databases were searched through August 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Descriptive, graphical, tabular, and quantitative data were extracted. The statistical outcomes (risk difference, RD) were synthesized under a random\u2010effects model. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses reporting guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 22 papers and 337 patients met the inclusion criteria for the literature review. Statistical analysis showed that the RD of overall survival (OS) rate at 1\u2010year was 32% (95% confidence interval [CI]: 21%\u201042%) for ligation and 70% (95% CI: 65%\u201076%) for reconstruction (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The RD for OS rate at 2\u2010year was 16% (95% CI: 7%\u201026%) for ligation and 39% (95% CI: 30%\u201047%) for reconstruction (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The RD for disease\u2010free survival rate at 1\u2010year was 27% (95% CI: 17%\u201038%)\u00a0for ligation and 60% (95% CI: 51%\u201070%) for reconstruction (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). There were no statistically significant differences (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05) between the 2\u00a0surgical modalities in terms of locoregional recurrence rate, carotid blowout rate, surgery\u2010related complications rate, neurological complications rate, and perioperative mortality rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review demonstrates the significant advantage of carotid artery reconstruction surgery in short\u2010term patient survival, thus making it a recommended option for HNC\u2010CA patients undergoing radical surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.824","type":"journal-article","created":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T04:30:13Z","timestamp":1716697813000},"page":"962-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Surgical Management Strategies for Carotid Artery Invasion by Head and Neck Cancer: Ligation Versus Reconstruction"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-9241","authenticated-orcid":false,"given":"Kai","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center The Affiliated BenQ Hospital of Nanjing Medical University Nanjing Jiangsu China"},{"name":"The Nanjing Medical Key Laboratory of Laryngopharynx and Head and Neck Neoplasm Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Nanjing Medical Key Laboratory of Laryngopharynx and Head and Neck Neoplasm Nanjing Jiangsu China"},{"name":"School of Medicine Southeast University Nanjing Jiangsu 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