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Meta\u2010analyses were performed on continuous measures (mean), proportions (%), and regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 69 studies were included with 8643 CRS patients and 703 control patients. The CRS group had a mean age of 44.1 (range: 16\u201082; 95% confidence interval [CI]: 40.3\u201048) and 86.1% [95% CI: 76.4\u201093.5] with nasal polyposis. The control group had a mean age of 39.2 (range: 17\u201088; 95% CI: 28.7\u201049.8). All CRS subgroups had significantly more severe headache and facial pain\/pressure when compared to the control (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Patients without polyps had significantly more severe facial pain\/pressure and headache when compared to patients with polyps (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Facial pain\/pressure is a moderate problem or worse in 29.8% of polypoid patients versus 56.4% of nonpolypoid patients; \u039426.6% [95% CI: 0.7\u201050;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.045].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Across all outcome metrics, CRS patients experience significantly more severe headache and facial pain\/pressure when compared to a control population. Nonpolypoid patients experience significantly more severe facial pain\/pressure and headache when compared to polypoid patients. The majority of nonpolypoid patients experience facial pain\/pressure that is moderate in severity or worse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.855","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T05:59:20Z","timestamp":1718776760000},"page":"1308-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Headache and Facial Pain\/Pressure in the Chronic Rhinosinusitis Population: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6127-7351","authenticated-orcid":false,"given":"Luke D.","family":"Heiland","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"},{"name":"Saint Louis University School of Medicine St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah G.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-4571","authenticated-orcid":false,"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"},{"name":"Department of Surgery Ralph H. 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