{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:50:37Z","timestamp":1790974237993,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the inflammatory profile of CRSwNP in Brazil and characterize the subgroups of CRSwNP patients in this population through cluster analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Multicenter cross\u2010sectional study involving 15 centers representing different regions of Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Clinical data of 166 patients and 80 controls, aged 18 to 70 years old, number of surgeries for CRS, history of asthma and aspirin sensitivity, and Lund\u2010Mackay scores on CT scans. During nasal endoscopy, we obtained the Lund\u2010Kennedy scores and collected 2 samples of nasal polyps: one for eosinophil and neutrophil tissue counts and one to quantify different cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>79.6% of our patients had 10 or more eosinophils\/HPF. CRSwNP groups exhibited significantly lower concentrations of TNF\u2010alpha and significantly higher concentrations of IFN\u2010gamma, CCL11\/Eotaxin, CCL24\/Eotaxin\u20102\/MPIF\u20102, and CCL26\/Eotaxin\u20103 versus the control group (Kruskal\u2010Wallis test). Comparison between CRSwNP groups (\u226510 vs &lt;10 eosinophils\/HPF) showed no difference in cytokine concentration (Mann\u2010Whitney test). Hierarchical clustering and PCA according to cytokine concentrations revealed 2 main Clusters, with a significantly higher concentration of all cytokines in Cluster 1 (n\u2009=\u200935) than in Cluster 2 (n\u2009=\u2009121), except IL\u20106 and IL\u201033 (Mann\u2010Whitney test). According to ROC curve analysis the best cut\u2010off to differentiate the 2 clusters was 43 eosinophils\/HPF. The group with \u226543 presented a higher prevalence of men and a higher Lund\u2010Mackay score (Mann\u2010Whitney test).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CRSwNP patients in Brazil present mixed inflammation, with 2 distinct groups (high and low inflammatory pattern) that can be distinguished by tissue eosinophilia of \u226543 eosinophils\/HPF cut\u2010off in nasal polyps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.904","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T09:34:14Z","timestamp":1722504854000},"page":"1552-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inflammatory Profile of Chronic Rhinosinusitis With Nasal Polyp Patients in Brazil: Multicenter Study"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2218-8417","authenticated-orcid":false,"given":"Fabrizio R.","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Ophtalmology, Otorhinolaryngology and Head and Neck Surgery University of Sao Paulo, FMRP\u2010USP S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana C. P.","family":"Valera","sequence":"additional","affiliation":[{"name":"Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeir\u00e3o Preto Medical School University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Fornazieri","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology State University of Londrina and PUC\u2010Paran\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia M. D.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Grupo de Excel\u00eancia M\u00e9dica State University of Londrina and PUC\u2010Paran\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel M.","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology at Santa Casa de Miseric\u00f3rdia Hospital of S\u00e3o Paulo FMRP\u2010USP S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo L. L.","family":"Dolci","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology at Santa Casa de Miseric\u00f3rdia Hospital of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Medical School Graduate Program University of Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo S. M.","family":"Freire","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Medical Sciences University of Brasilia Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eul\u00e1lia","family":"Sakano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology\/Otorhinolaryngology of the Science Medical School of Sao Paulo State University Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana D. C.","family":"Toro","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medical Sciences State University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo M.","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery at Paulista School of Medicine Federal University of Sao Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano L.","family":"Gregorio","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco C. J.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Catholic University of Parana Parana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eco Medical Center, Curitiba Parana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilio M.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Famerp S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis L.","family":"Moras","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Famerp S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A. G.","family":"Avelino","sequence":"additional","affiliation":[{"name":"Department at Goi\u00e1s Federal University Goi\u00e1s Federal University Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Federal University of Goias Goias Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus M.","family":"Lessa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Otorhinolaryngology of the Federal University of Bahia Medical School Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiana do C.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Medical Sciences Federal University of Bahia Medical School Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Roithmann","sequence":"additional","affiliation":[{"name":"Otolaryngology Department of Otolaryngology\u2013Head and Neck Surgery Universidade Luterana do Brasil Porto Alegre Brazil"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai Hospital Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Redeker","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Universidade Luterana do Brazil  Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-9743","authenticated-orcid":false,"given":"Miguel S.","family":"Tepedino","sequence":"additional","affiliation":[{"name":"Division of Clinical Otorhinolaryngology, Hospital Universit\u00e1rio Pedro Ernesto Universidade do Estado do Rio de Janeiro, Policl\u00ednica de Botafogo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M.","family":"Vianna","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Medical Residency Program of Otorhinolaryngology at Army Central Hospital\u2013RJ, Rhinology and Skull Base Endoscopic Surgery Team at HUPE\u2010UERJ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00e1vio B.","family":"Piltcher","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology School of Medicine, Federal University of Rio Grande do Sul Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila D.","family":"Meotti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital de Clinicas de Porto Alegre, Surgical Sciences at Universidade Federal do Rio Grande do Sul, Rhinology at Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago F. P.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Federal University of Pernambuco Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Voegels","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata R.","family":"de Mendon\u00e7a Pilan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana de A.","family":"Batista Murashima","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian E. C. 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