{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:17:27Z","timestamp":1787066247502,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Noise\u2010induced hearing loss (NIHL) often presents with an insidious onset, resulting from the cumulative effect of chronic, high\u2010level noise exposure regardless of etiology. Stereocilin (STRC) is a protein that supports stereocilia attachment and cochlear hair cell function, 2 common targets of noise trauma. In this study, we explored the relationship between STRC and daily noise exposure in young, healthy adults. We found that higher noise exposure levels were associated with lower serum levels of STRC, as was the case for another inner\u2010ear protein, prestin. There was a statistically significant positive correlation between serum STRC and prestin levels. These results support a biomarker approach for the diagnosis and monitoring of NIHL. The ability to detect and measure STRC in the blood also has implications for targeted gene therapy. STRC mutations are known to be associated with autosomal recessive deafness, a condition that is now amenable to targeted gene therapy.<\/jats:p>","DOI":"10.1002\/ohn.915","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T03:59:35Z","timestamp":1721534375000},"page":"1934-1937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Levels of Stereocilin as a Hearing Biomarker"],"prefix":"10.1002","volume":"171","author":[{"given":"Carly","family":"Malesky","sequence":"first","affiliation":[{"name":"University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Daniel","sequence":"additional","affiliation":[{"name":"Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Skoe","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences University of Connecticut Storrs Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-6019","authenticated-orcid":false,"given":"Kourosh","family":"Parham","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of Connecticut Health Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Institute on Deafness and Other Communication Disorders. Noise\u2010induced hearing loss. NIDCD. December 14 2018. Accessed March 17 2024.http:\/\/www.nidcd.nih.gov\/health\/noise-induced-hearing-loss"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijoem.IJOEM_43_18"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05131-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22509"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902781116"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.05.049"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000001026"},{"key":"e_1_2_8_9_1","unstructured":"NIOSH.Criteria for a Recommended Standard: Occupational Noise Exposure (Revised Criteria 1998). No. 98e126. NIOSH;1998."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031046"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02874-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.707845"},{"key":"e_1_2_8_13_1","unstructured":"The Human Protein Atlas. Tissue expression of STRC\u2014summary. 2023. Accessed June 4 2024.https:\/\/www.proteinatlas.org\/ENSG00000242866-STRC\/tissue"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8195-y"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:11:21Z","timestamp":1760955081000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ohn.915"],"URL":"https:\/\/doi.org\/10.1002\/ohn.915","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,21]]},"assertion":[{"value":"2024-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}