{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:23:16Z","timestamp":1772990596476,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Near\u2010infrared autofluorescence (NIRAF) characteristics of parathyroid glands in primary hyperparathyroidism (pHPT) vary, with unclarity regarding the underlying mechanism. Similarly,\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010sestamibi uptake in diseased parathyroid glands is variable. There is a suggestion that oxyphilic cell content may influence both imaging modalities. This study aims to analyze the relationship between NIRAF imaging characteristics,\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010sestamibi uptake, and cellular composition in pHPT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective analysis of an Institutional Review Board\u2010monitored prospective database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      NIRAF characteristics of parathyroid glands of patients with pHPT between 2019 and 2024 were compared with\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010sestamibi scan findings from a prospective database. Using third\u2010party software, brightness intensity and heterogeneity index (HI) of the glands were calculated. A subgroup of parathyroid glands obtained from consecutive patients with pHPT in 2020 to 2021 underwent histological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 428 patients with 638 diseased parathyroid glands were analyzed. Forty\u2010seven percent of the glands showed an uptake on\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010sestamibi scans. The brightness intensity of the NIRAF signals from parathyroid glands that were seen versus not seen on sestamibi was 2.1 versus 2.3 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002) and HI 0.18 versus 0.17 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.35), respectively. On multivariate analysis, low autofluorescence intensity, high gland volume, and single adenoma were associated with detectability on\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010sestamibi scan (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Intraglandular adipose tissue content was lower in diseased glands that were detected on\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010sestamibi scans (0% vs 5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings indicate an inverse relationship between autofluorescence intensity and detectability on\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010sestamibi scans and a lack of correlation between different cell types and autofluorescence properties.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.948","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T07:09:31Z","timestamp":1723964971000},"page":"1341-1348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Near\u2010Infrared Autofluorescence Properties and Sestamibi Uptakes of Parathyroid Glands in Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9970-9022","authenticated-orcid":false,"given":"Ege","family":"Akgun","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-4434","authenticated-orcid":false,"given":"Arturan","family":"Ibrahimli","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-4326","authenticated-orcid":false,"given":"Mobeen","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-3185","authenticated-orcid":false,"given":"Christopher","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-9286","authenticated-orcid":false,"given":"Eren","family":"Berber","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Cleveland Clinic Cleveland Ohio USA"},{"name":"Department of General Surgery Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.06.051"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3583571"},{"key":"e_1_2_7_4_1","unstructured":"Food and Drug Administration. 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