{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:26:02Z","timestamp":1778037962676,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the accuracy of diffusion\u2010weighted magnetic resonance imaging (DWI\u2010MRI) in diagnosing persistent\/recurrent head and neck squamous cell carcinomas (HNSCCs) after primary chemoradiotherapy (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Scopus, PubMed\/MEDLINE, and Cochrane Library databases were searched for relevant publications until April 18, 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses of Diagnostic Test Accuracy statement. The search was conducted independently by 2 investigators. Methodological quality of included studies was assessed using the Quality Assessment of Diagnostic Studies\u20102 questionnaire. Extracted data were used to calculate the pooled DWI\u2010MRI sensitivity, specificity, diagnostic odds ratio, and positive and negative likelihood ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 618 patients from 10 studies were included for calculation of diagnostic accuracy parameters. At the level of the primary tumor, the pooled sensitivity and specificity were, respectively, 0.96 (95% confidence interval [CI]: 0.89\u20101.00) and 0.81 (95% CI: 0.54\u20100.98) in the case of qualitative analysis, and, respectively, 0.79 (95% CI: 0.66\u20100.89) and 0.88 (95% CI: 0.77\u20100.96) for quantitative analysis. At the level of the neck, the pooled sensitivity and specificity were, respectively, 0.87 (95% CI: 0.75\u20100.95) and 0.84 (95% CI: 0.74\u20100.93) when images were analyzed qualitatively, and 0.79 (95% CI: 0.60\u20100.94) and 0.90 (95% CI: 0.82\u20100.97) when analyzed quantitatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DWI\u2010MRI showed high diagnostic accuracy and should be considered if persistent\/recurrent HNSCCs is suspected after primary CRT. No significant differences were found between qualitative and quantitative imaging assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.949","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T07:13:38Z","timestamp":1723965218000},"page":"13-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diffusion\u2010Weighted MRI for Recurrent\/Persistent Head and Neck Squamous\u2010Cell Carcinoma After Radiotherapy: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9957-149X","authenticated-orcid":false,"given":"Luca","family":"Canali","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Pieve Emanuele Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital Milan Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-7785","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery AdventHealth Orlando Celebration Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Mari","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Pieve Emanuele Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital Milan Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Maria","family":"Festa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Pieve Emanuele Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital Milan Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Pieve Emanuele Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital Milan Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Giannitto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Pieve Emanuele Italy"},{"name":"Radiology Unit IRCCS Humanitas Research Hospital Milan Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Spriano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Pieve Emanuele Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital Milan Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"De Virgilio","sequence":"additional","affiliation":[{"name":"Department of \u2018Organi di Senso\u2019 University \u201cSapienza\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60728-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053422"},{"key":"e_1_2_8_4_1","unstructured":"National Comprehensive Cancer Network.Head and neck cancers (version 3.2024).2024. 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