{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:07:01Z","timestamp":1792642021219,"version":"4.5.0"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chronic dizziness after acute unilateral vestibulopathy (AUVP) causes significant social and economic burdens. This study aims to identify predictors of chronic dizziness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, longitudinal cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>ENT departments from secondary and tertiary hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants meeting the Barany Society's diagnostic criteria for AUVP were included. Evaluations occurred within 0 to 21 days (T1), and at 4 (T2) and 10 weeks (T3) postonset. The primary outcome measure was the Dizziness Handicap Inventory (DHI) at 6 months, with a score\u2009&gt;30 indicating chronic dizziness. Five clusters of predictors were assessed at T1\u20103: central vestibular compensation, visual dependence, movement exposure, psychological factors, and balance performance. Separate linear regression models for T1, T2, and T3 were constructed to explain the variability in the 6\u2010month DHI score. Receiver operating characteristics analyses were conducted to predict chronic dizziness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From June 2021 to January 2024, 103 participants (55.2\u2009\u00b1\u200916.6 years old, 49 women) were included. The regression models explained the variability in the 6\u2010month DHI score by 33.0% at T1, 47.6% at T2, and 64.0% at T3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), including psychological factors (T1, T2, T3), visual dependence (T2, T3), and static balance performance (T3). Cutoff values for the Vestibular Activities Avoidance Instrument (23\/54), Visual Vertigo Analog Scale (33.5\/100), and Hospital Anxiety and Depression Scale\u2010Anxiety (7.5\/21) at 10 weeks postonset predicted chronic dizziness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher psychological burden, increased visual dependence, and poorer static balance performance were associated with chronic dizziness. Cutoff values were determined to identify individuals with AUVP at risk for chronic dizziness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.964","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T03:35:30Z","timestamp":1725334530000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of Chronic Dizziness in Acute Unilateral Vestibulopathy: A Longitudinal Prospective Cohort Study"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-9300","authenticated-orcid":false,"given":"Lien","family":"Van Laer","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy\/Movant, Faculty of Medicine and Health Science University of Antwerp Antwerp Belgium"},{"name":"Department of Rehabilitation Sciences and Physiotherapy\/Movant, Faculty of Medicine and Health Science Multidisciplinary Motor Centre Antwerp (M\u00b2OCEAN) University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hallemans","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy\/Movant, Faculty of Medicine and Health Science University of Antwerp Antwerp Belgium"},{"name":"Department of Rehabilitation Sciences and Physiotherapy\/Movant, Faculty of Medicine and Health Science Multidisciplinary Motor Centre Antwerp (M\u00b2OCEAN) University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"De Somer","sequence":"additional","affiliation":[{"name":"Vzw Sint\u2010Lievenspoort, Centrum voor Ambulante Revalidatie Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Janssens de Varebeke","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jessa Hospital Hasselt Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Fransen","sequence":"additional","affiliation":[{"name":"Center of Medical Genetics, Faculty of Medicine and Health Science, Antwerp University Hospital University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Laboratory of Vestibular NeuroAdaptation, The Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Van Rompaey","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Antwerp University Hospital Edegem Belgium"},{"name":"Department of Translational Neurosciences Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Vereeck","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy\/Movant, Faculty of Medicine and Health Science University of Antwerp Antwerp Belgium"},{"name":"Department of Rehabilitation Sciences and Physiotherapy\/Movant, Faculty of Medicine and Health Science Multidisciplinary Motor Centre Antwerp (M\u00b2OCEAN) University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"37","article-title":"Vestibular function after acute vestibular neuritis","volume":"28","author":"Halmagyi GM","year":"2010","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7903-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08192-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950180243"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.12.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.48"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510043477"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03721.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000949"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-310319"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00208-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90107-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02599633"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb02091.x"},{"issue":"429","key":"e_1_2_9_16_1","first-page":"1131","article-title":"Prevalence and presentation of dizziness in a general practice community sample of working age people","volume":"48","author":"Yardley L","year":"1998","journal-title":"Br J Gen Pract"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0697-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5287-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-201531"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0000000000000382"},{"issue":"4","key":"e_1_2_9_21_1","first-page":"541","article-title":"Is vestibular rehabilitation effective in improving dizziness and function after unilateral peripheral vestibular hypofunction? An abridged version of a Cochrane Review","volume":"52","author":"Hillier S","year":"2016","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7913-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1254105"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1254080"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2020.04.016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10228-4"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330196"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002669"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.386"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.10.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000231501.46534.30"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000140004.06247.c9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-220201"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00258"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4055-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63437-5.00009-1"},{"issue":"2","key":"e_1_2_9_37_1","first-page":"75","article-title":"Test\u2010retest reliability of the Dutch version of the Dizziness Handicap Inventory","volume":"2","author":"Vereeck L","year":"2006","journal-title":"B\u2010ENT"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870040046011"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200403000-00010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003448"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2289"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-101"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28505"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-2011-0412"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.880714"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/s19245344"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.925801"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004382"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzad094"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002757"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_157_18"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2012.300897"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.735"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318151a4dd"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309135846"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2016.00948"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.304"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1129569"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.872892"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42441-2"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11107-w"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2005.09.008"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.118127"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-019-0452-3"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102609"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7914-1"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005698"},{"issue":"1","key":"e_1_2_9_70_1","first-page":"57","article-title":"Postural compensation for vestibular loss and implications for rehabilitation","volume":"28","author":"Horak FB","year":"2010","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2016.1203027"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0476-2"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-120462"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968312461715"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(03)00257-2"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.09.012"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000004006"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.7874\/jao.2023.00066"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192705"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-2011-0429"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:29:26Z","timestamp":1760966966000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ohn.964"],"URL":"https:\/\/doi.org\/10.1002\/ohn.964","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"2024-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}