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Among all compounds tested, the 5\u2032\u2010O\u2010tritylated and the 5\u2032\u2010O\u2010dimethoxytritylated 5\u2010fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5\u2032O, N\u2010bis\u2010tritylated fludarabine derivative revealed strong inhibitory activity against DENV at \u03bc<jats:sc>m<\/jats:sc> concentrations, however significantly weaker potency against YFV.<\/jats:p>","DOI":"10.1002\/open.201500216","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T11:20:21Z","timestamp":1453375221000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anti\u2010flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues"],"prefix":"10.1002","volume":"5","author":[{"given":"Christopher","family":"McGuigan","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  King Edward VII Avenue Cardiff CF10 3NB United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Serpi","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  King Edward VII Avenue Cardiff CF10 3NB United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Slusarczyk","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  King Edward VII Avenue Cardiff CF10 3NB United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ferrari","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  King Edward VII Avenue Cardiff CF10 3NB United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Pertusati","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  King Edward VII Avenue Cardiff CF10 3NB United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Meneghesso","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  King Edward VII Avenue Cardiff CF10 3NB United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Derudas","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  King Edward VII Avenue Cardiff CF10 3NB United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Farleigh","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Infectious Diseases School of Medicine Cardiff University  Heath Park Cardiff CF14 4XN United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zanetta","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Infectious Diseases School of Medicine Cardiff University  Heath Park Cardiff CF14 4XN United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Bugert","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Infectious Diseases School of Medicine Cardiff University  Heath Park Cardiff CF14 4XN United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4010"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00788-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.02.009"},{"key":"e_1_2_6_5_1","unstructured":"\u00a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471220574"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)01645-8"},{"key":"e_1_2_6_8_1","unstructured":"\u00a0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)78579-0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(90)80033-Y"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1023\/A:1016247817737","volume":"8","author":"de La Torre B.","year":"2002","journal-title":"Lett. 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