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The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel\u2010formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles. NMR spectroscopy studies proved that these gels kept the drug not only at the interstitial space but also within the fibers. Due to the design of the gelator, drug release was up to 10\u2005times faster and retention of the drug within the skin was up to 20\u2005times more effective than that observed for commercial products. Experiments in\u2005vivo demonstrated the rapid efficacy of these gels in reducing erythema, especially in the case of the gel with brimonidine. 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