{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:06:52Z","timestamp":1792199212691,"version":"4.4.0"},"reference-count":142,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005721","name":"Universit\u00e4t Bielefeld","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gluten\u2010related disorders are a complex group of diseases that involve the activation of the immune system triggered by the ingestion of gluten. Among these, celiac disease, with a prevalence of 1\u2009%, is the most investigated, but recently, a new pathology, named nonceliac gluten sensitivity, was reported with a general prevalence of 7\u2009%. Finally, there other less\u2010prevalent gluten\u2010related diseases such as wheat allergy, gluten ataxia, and dermatitis herpetiformis (with an overall prevalence of less than 0.1\u2009%). As mentioned, the common molecular trigger is gluten, a complex mixture of storage proteins present in wheat, barley, and a variety of oats that are not fully degraded by humans. The most\u2010studied protein related to disease is gliadin, present in wheat, which possesses in its sequence many pathological fragments. Despite a lot of effort to treat these disorders, the only effective method is a long\u2010life gluten\u2010free diet. This Review summarizes the actual knowledge of gluten\u2010related disorders from a translational chemistry point of view. We discuss what is currently known from the literature about the interaction of gluten with the gut and the critical host responses it evokes and, finally, connect them to our current and novel molecular understanding of the supramolecular organization of gliadin and the 33\u2010mer gliadin peptide fragment under physiological conditions.<\/jats:p>","DOI":"10.1002\/open.201700197","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T02:53:25Z","timestamp":1519700005000},"page":"217-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Translational Chemistry Meets Gluten\u2010Related Disorders"],"prefix":"10.1002","volume":"7","author":[{"given":"Karen M.","family":"Lammers","sequence":"first","affiliation":[{"name":"Laboratory Immunogenetics, Department of Medical Microbiology and Infection Control VU University Medical Center  1081 Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Biochemistry Institute of biological chemistry and Physicochemical CONICET-University of Buenos Aires  Jun\u00edn 956 C1113AAD Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7937-1880","authenticated-orcid":false,"given":"Veronica I.","family":"Dodero","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Organic Chemistry III Bielefeld University  Universit\u00e4tsstra\u00dfe 25 33615 Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0b013e3181ccd618"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026614666140118220825"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201500061"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.12.049"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"},{"key":"e_1_2_12_6_1","unstructured":"\u00a0"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.006"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31827913f9"},{"key":"e_1_2_12_9_1","unstructured":"\u00a0"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.07.030"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-19-88"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0312-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i23.7110"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-13"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i42.6036"},{"key":"e_1_2_12_16_1","unstructured":"\u00a0"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283365263"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.131"},{"key":"e_1_2_12_19_1","unstructured":"\u00a0"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807917"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0352-1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.00788"},{"key":"e_1_2_12_23_1","unstructured":"\u00a0"},{"key":"e_1_2_12_24_2","first-page":"241","volume":"20","author":"Barratt S. M.","year":"2011","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-016-1238-5"},{"key":"e_1_2_12_26_1","unstructured":"\u00a0"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.195131"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8530"},{"key":"e_1_2_12_29_1","unstructured":"\u00a0"},{"key":"e_1_2_12_30_2","first-page":"12","volume":"10","author":"Szaflarska-Poplawska A.","year":"2015","journal-title":"Prz. Gastroenterol."},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2015.985204"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.031"},{"key":"e_1_2_12_33_1","unstructured":"\u00a0"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i35.5837"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.11.053"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03413.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4040243"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2006.07.004"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.102.1.61"},{"key":"e_1_2_12_40_1","first-page":"55","volume":"41","author":"Tatham A. S.","year":"2000","journal-title":"Methods Mol. Med."},{"key":"e_1_2_12_41_1","unstructured":"\u00a0"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074129"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00136.2002"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.22763"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00396-014-3317-6"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252285"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1006\/jcrs.1996.0100"},{"key":"e_1_2_12_48_1","unstructured":"\u00a0"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1094\/CCHEM.2000.77.5.607"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2670001"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0248(95)00245-6"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118523063.ch4"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi027059y"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-5210(85)80021-7"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku316"},{"key":"e_1_2_12_56_1","unstructured":"\u00a0"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2014.09.008"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00701-9"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.155.3759.203"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b02902"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.02.019"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00095-7"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1057"},{"key":"e_1_2_12_64_1","unstructured":"\u00a0"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.001415"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095910"},{"key":"e_1_2_12_67_1","unstructured":"\u00a0"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.5.643"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.2.215"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70134-9"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/11341"},{"key":"e_1_2_12_72_1","unstructured":"\u00a0"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930802350789"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1159\/000260087"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.06.026"},{"key":"e_1_2_12_76_1","unstructured":"\u00a0"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.2.218"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.085373"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.023"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906773106"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.086637"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2512"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520500235334"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02169-3"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089068"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2670"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00223-1"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.06.020"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.02.017"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.118265"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3919"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03378.x"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.4.625"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.06.057"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062426"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102660"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138338"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06878"},{"key":"e_1_2_12_99_1","unstructured":"\u00a0"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802624177"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03662.x"},{"key":"e_1_2_12_102_1","unstructured":"\u00a0"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12911"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0501-x"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr050173t"},{"key":"e_1_2_12_106_1","unstructured":"\u00a0"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.05.009"},{"key":"e_1_2_12_108_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609004874"},{"key":"e_1_2_12_109_1","unstructured":"\u00a0"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13803-2"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010001"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00435.2015"},{"key":"e_1_2_12_113_1","unstructured":"\u00a0"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012246"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.603"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.183608"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.987"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10874"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45092"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.136366"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.10.019"},{"key":"e_1_2_12_122_1","unstructured":"\u00a0"},{"key":"e_1_2_12_123_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071204"},{"key":"e_1_2_12_124_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04032.x"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.148007"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066474"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040034"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310148"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207606200"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22288"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SM01619C"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.04.012"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527610754.pp08"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457371"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3810"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209527109"},{"key":"e_1_2_12_137_1","unstructured":"\u00a0"},{"key":"e_1_2_12_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(96)80016-9"},{"key":"e_1_2_12_139_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4OB02589J"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.5b11380"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.217"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2424306"}],"container-title":["ChemistryOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fopen.201700197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.201700197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:37:32Z","timestamp":1760971052000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/open.201700197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,27]]},"references-count":142,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/open.201700197"],"URL":"https:\/\/doi.org\/10.1002\/open.201700197","archive":["Portico"],"relation":{},"ISSN":["2191-1363","2191-1363"],"issn-type":[{"value":"2191-1363","type":"print"},{"value":"2191-1363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,27]]},"assertion":[{"value":"2017-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}