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This catalytic approach produced the desired products in a simple operation and low catalyst loading with acceptable yield of the new hybrids. All tested compounds were subjected for biological activity on \u03b1\u2010glucosidase and \u03b1\u2010amylase. The results revealed that all synthesized compounds exhibited very good activity against both enzymes when compared to positive control (acarbose). Moreover, compound <jats:bold>5o<\/jats:bold> showed the best activity whereas its IC<jats:sub>50<\/jats:sub> (<jats:italic>\u03bc<\/jats:italic>M) are 13.02+0.01 and 21.71+0.82 for <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase and <jats:italic>\u03b1<\/jats:italic>\u2010amylase respectively. Both compounds <jats:bold>5o<\/jats:bold> and <jats:bold>5l<\/jats:bold> exhibited high similarity in binding mode and pose with amylase protein (4UAC). The obtained data may be used for developing potential hypoglycemic agents.<\/jats:p>","DOI":"10.1002\/open.201900240","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T09:01:00Z","timestamp":1571734860000},"page":"1288-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Synthesis and Inhibitory Effect of Some Indole\u2010Pyrimidine Based Hybrid Heterocycles on \u03b1\u2010Glucosidase and \u03b1\u2010Amylase as Potential Hypoglycemic Agents"],"prefix":"10.1002","volume":"8","author":[{"given":"Farid A.","family":"Badria","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of pharmacy Mansura University  Mansura 35516 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Atef","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science King Saud University  P. O. 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