{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:29:46Z","timestamp":1761006586920,"version":"build-2065373602"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009122","name":"Ministry of Higher Education and Scientific Research","doi-asserted-by":"publisher","award":["2020R1I1A3053400"],"award-info":[{"award-number":["2020R1I1A3053400"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The conformational preferences of oligopeptides of an \u03f5\u2010amino acid (2\u2010((1<jats:italic>R<\/jats:italic>,3<jats:italic>S<\/jats:italic>)\u20103\u2010(aminomethyl)cyclopentyl)acetic acid, Amc<jats:sub>5<\/jats:sub>a) with a cyclopentane substituent in the C<jats:sup>\u03b2<\/jats:sup>\u2212C<jats:sup>\u03b3<\/jats:sup>\u2212C<jats:sup>\u03b4<\/jats:sup> sequence of the backbone were investigated using DFT methods in chloroform and water. The most preferred conformation of Amc<jats:sub>5<\/jats:sub>a oligomers (dimer to hexamer) was the H<jats:sub>16<\/jats:sub>\u2005helical structure both in chloroform and water. Four residues were found to be sufficient to induce a substantial H<jats:sub>16<\/jats:sub> helix population in solution. The Amc<jats:sub>5<\/jats:sub>a hexamer adopted a stable left\u2010handed (<jats:italic>M<\/jats:italic>)\u20102.3<jats:sub>16<\/jats:sub> helical conformation with a rise of 4.8\u2005\u00c5 per turn. The hexamer of Ampa (an analogue of Amc<jats:sub>5<\/jats:sub>a with replacing cyclopentane by pyrrolidine) adopted the right\u2010handed mixed (<jats:italic>P<\/jats:italic>)\u20102.9<jats:sub>18\/16<\/jats:sub> helical conformation in chloroform and the (<jats:italic>M<\/jats:italic>)\u20102.4<jats:sub>16<\/jats:sub> helical conformation in water. Therefore, hexamers of \u03f5\u2010amino acid residues exhibited different preferences of helical structures depending on the substituents in peptide backbone and the solvent polarity as well as the chain length.<\/jats:p>","DOI":"10.1002\/open.202100253","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T03:58:14Z","timestamp":1643255894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Helical Folding in Oligomers of Cyclopentane\u2010Based \u03f5\u2010Amino Acids: A Computational Study"],"prefix":"10.1002","volume":"11","author":[{"given":"Hae Sook","family":"Park","sequence":"first","affiliation":[{"name":"Department of Nursing Cheju Halla University  Cheju 63092 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-8922","authenticated-orcid":false,"given":"Young 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