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As alcohols, primary, secondary, and tertiary alcohols could be used, and the use of <jats:italic>tert<\/jats:italic>\u2010butyl alcohol yielded the products with a higher enantiomeric ratio. A substrate with two different alkyl groups on the phosphorus atom could also participate in the substitution reaction to give the corresponding products in good yields with excellent selectivity. The molecular structures of one of the substrates and the corresponding products, determined by X\u2010ray analyses, proved that the substitution reaction at the phosphorus atom proceeded with inversion of the absolute configuration. The usefulness of the reaction was demonstrated by using it to prepare a drug candidate for Duchenne muscular dystrophy. Finally, thionation of the resulting phosphinates was carried out to form <jats:italic>P<\/jats:italic>\u2010chirogenic phosphinothioates.<\/jats:p>","DOI":"10.1002\/open.202100294","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T01:42:01Z","timestamp":1646790121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Stereoselective Transesterification of <i>P<\/i>\u2010Chirogenic Hydroxybinaphthyl Phosphinates"],"prefix":"10.1002","volume":"11","author":[{"given":"Akari","family":"Kawajiri","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Faculty of Engineering Gifu University Yanagido  Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-253X","authenticated-orcid":false,"given":"Taro","family":"Udagawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Faculty of Engineering Gifu University Yanagido  Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-0318","authenticated-orcid":false,"given":"Mao","family":"Minoura","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science Rikkyo University Nishi-ikebukuro, Toshima-ku  Tokyo 171-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4945-0996","authenticated-orcid":false,"given":"Toshiaki","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biomolecular Science Faculty of Engineering Gifu University Yanagido  Gifu 501-1193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"For books see:"},{"key":"e_1_2_8_2_2","unstructured":"Phosphorus Chemistry IinTopics in Current Chemistry volume 360(ed. 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