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The required allyl alcohol was prepared from a Wieland\u2010Miescher ketone using a known \u03b3\u2010hydroxylation, reduction of the enone double bond, cyanohydrin formation, and elimination, yielding an unsaturated nitrile. A two\u2010step reduction led to the required allyl alcohol. The subsequent Johnson\u2010Claisen rearrangement provided a mixture of two diastereomeric 1,4\u2010unsaturated esters in a ratio of around 2.6\u2009:\u20091. The major isomer could be converted to a key intermediate of the Hagiwara synthesis of salvinorin A.<\/jats:p>","DOI":"10.1002\/open.202200015","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T03:23:45Z","timestamp":1645845825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Formal Total Synthesis of Salvinorin A"],"prefix":"10.1002","volume":"11","author":[{"given":"Marc","family":"Halang","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Organische Chemie Eberhard Karls Universit\u00e4t T\u00fcbingen  Auf der Morgenstelle 18 72076 T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-4943","authenticated-orcid":false,"given":"Martin E.","family":"Maier","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische Chemie Eberhard Karls Universit\u00e4t T\u00fcbingen  Auf der 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