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Aiming to kill artemisinin\u2010resistant <jats:italic>Plasmodium<\/jats:italic>, a series of novel hybrid drugs named Atokels were synthesized and characterized. Atokels are based on an 8\u2010amino\u2010 or 8\u2010hydroxyquinoline entity covalently bound to a 1,4\u2010naphthoquinone through a polyamine linker. These drugs have been designed to target the parasite mitochondrion by their naphthoquinone moiety reminiscent of the antimalarial drug atovaquone, and to trigger a damaging oxidative stress due to their ability to chelate metal ions in order to generate redox active complexes in\u2005situ. The most effective Atokel drug shown a promising antimalarial activity (IC<jats:sub>50<\/jats:sub>=622\u2005n<jats:sc>m<\/jats:sc> on an artemisinin\u2010resistant <jats:italic>P. falciparum<\/jats:italic> strain) and no cytotoxicity at 50\u2005\u03bc<jats:sc>m<\/jats:sc> indicating a specific antiplasmodial mode of action.<\/jats:p>","DOI":"10.1002\/open.202200064","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T05:44:41Z","timestamp":1652247881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis and Antimalarial Activities of New Hybrid Atokel Molecules"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-9314","authenticated-orcid":false,"given":"Youzhi","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong University of Technology School of Chemical Engineering and Light Industry  no. 100 Waihuan Xi road Education Mega Center Guangzhou 510006 P. 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