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All compounds are mononuclear. The introduction of a monodentate <jats:italic>N<\/jats:italic>\u2010heteroaromatic base (3,4\u2010dimethylpyridine) has led to a significant increase of antimicrobial activity against Gram\u2010negative <jats:italic>Escherichia coli<\/jats:italic> and antifungal activity against <jats:italic>Candida albicans<\/jats:italic> compared to the pro\u2010ligand and the precursor complex [Cu(L)H<jats:sub>2<\/jats:sub>O]. The introduction of bidentate <jats:italic>N<\/jats:italic>\u2010heteroaromatic bases did not lead to such increase of antimicrobial and antifungal activities. Moreover, complex <jats:bold>3<\/jats:bold> surpasses the inhibitory activity of tetracycline toward <jats:italic>Enterobacter cloacae<\/jats:italic> and the inhibitory activity of fluconazole toward <jats:italic>Candida parapsilosis<\/jats:italic> and <jats:italic>Cryptococcus neoformans<\/jats:italic>. The study of antioxidant activity against cation radicals ABTS\u22c5<jats:sup>+<\/jats:sup> showed that complexes <jats:bold>1<\/jats:bold>\u2013<jats:bold>3<\/jats:bold> are more active than Trolox, but only introduction of the monodentate <jats:italic>N<\/jats:italic>\u2010heteroaromatic base (3,4\u2010dimethylpyridine) led to the increase of antioxidant properties compared to the precursor complex.<\/jats:p>","DOI":"10.1002\/open.202200208","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T08:08:35Z","timestamp":1671610115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Introducing <i>N<\/i>\u2010Heteroaromatic Bases into Copper(II) Thiosemicarbazon Complexes: A Way to Change their Biological Activity"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3345-7539","authenticated-orcid":false,"given":"Ianina","family":"Ulchina","sequence":"first","affiliation":[{"name":"Laboratory of Advanced Materials in Biofarmaceutics and Technics Moldova State University  Chi\u015fin\u0103u 2009 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-2153","authenticated-orcid":false,"given":"Vasilii","family":"Graur","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials in Biofarmaceutics and Technics Moldova State University  Chi\u015fin\u0103u 2009 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-3116","authenticated-orcid":false,"given":"Victor","family":"Tsapkov","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials in Biofarmaceutics and Technics Moldova State University  Chi\u015fin\u0103u 2009 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-992X","authenticated-orcid":false,"given":"Yurii","family":"Chumakov","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Methods of Solid State Investigation \u201cTadeusz Malinowski\u201d Institute of Applied Physics  Chi\u015fin\u0103u 2028 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-892X","authenticated-orcid":false,"given":"Olga","family":"Garbuz","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials in Biofarmaceutics and Technics Moldova State University  Chi\u015fin\u0103u 2009 Republic of Moldova"},{"name":"Institute of Zoology Academy of Sciences of Moldova  Chi\u015fin\u0103u 2028 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-0800","authenticated-orcid":false,"given":"Olga","family":"Burduniuc","sequence":"additional","affiliation":[{"name":"State University of Medicine and Pharmacy \u201cNicolae Testemi\u0163anu\u201d  Chi\u015fin\u0103u 2004 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-2884","authenticated-orcid":false,"given":"Emil","family":"Ceban","sequence":"additional","affiliation":[{"name":"State University of Medicine and Pharmacy \u201cNicolae Testemi\u0163anu\u201d  Chi\u015fin\u0103u 2004 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-7959","authenticated-orcid":false,"given":"Aurelian","family":"Gulea","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials in Biofarmaceutics and Technics Moldova State University  Chi\u015fin\u0103u 2009 Republic of Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"34","volume":"6","author":"Arora S.","year":"2014","journal-title":"Int. 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