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Hence, choosing an appropriate capping agent is a critical step in both synthesis and biomedical application of QDs. In this research, ZnS QDs were synthesized via chemical precipitation process and three commonly employed capping agents, namely mercaptoethanol (ME), mercaptoacetic acid (MAA), and cysteamine (CA), were used to stabilize the QDs. This study was aimed to examine how these capping agents impact the physicochemical and optical characteristics of ZnS QDs, as well as their interactions with biological systems. The findings revealed that the capping agents had considerable effects on the behavior and properties of ZnS QDs. MAA\u2010QD exhibited superior crystal lattice, smaller size, and significant quantum yield (QY). In contrast, CA\u2010QDs demonstrated the lowest QY and the highest tendency for aggregation. ME\u2010QDs exhibited intermediate characteristics, along with an acceptable level of cytotoxicity, rapid uptake by cells, and efficient escape from lysosomes. Consequently, it is advisable to select capping agents in accordance with the specific objectives of the research.<\/jats:p>","DOI":"10.1002\/open.202300094","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T01:34:44Z","timestamp":1696642484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exploring the Effects of Various Capping Agents on Zinc Sulfide Quantum Dot Characteristics and In\u2010vitro Fate"],"prefix":"10.1002","volume":"12","author":[{"given":"Zohre","family":"Montaseri","sequence":"first","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Pharmaceutical Nanotechnology Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mohammad","family":"Tamaddon","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Pharmaceutical Nanotechnology Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad","family":"Raee","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5964-3364","authenticated-orcid":false,"given":"Fakhrossadat","family":"Farvadi","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102308"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnsc.2019.11.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.12.078"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906399"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/b915139g"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2022-0136"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcata.2015.01.029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mssp.2016.02.021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.05.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00160a005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac022124v"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-012-0867-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm00007h"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/18\/20\/205604"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2016.08.158"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.44"},{"key":"e_1_2_9_17_1","first-page":"1904","volume":"10","author":"Di Pompo G.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbsr.2014.12.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2005.151"},{"key":"e_1_2_9_20_1","first-page":"012010","volume-title":"J. 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