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Despite considerable attention to this research area over the years, an environmentally friendly and practical method for synthesizing (\u2212)\u2010ambrox has remained elusive. This study presents a succinct and efficient approach to (\u2212)\u2010ambrox synthesis, involving two consecutive alkylations at C\u20106, followed by an acid\u2010catalyzed cyclization to give bicyclic ketones starting from (<jats:italic>R<\/jats:italic>)\u2010carvone. Subsequent reduction, Barton Vinyl Iodide synthesis, alkylation, and an acid\u2010catalyzed cyclization collectively achieved the synthesis of (\u2212)\u2010ambrox with a satisfactory yield of 26.2\u2009%.<\/jats:p>","DOI":"10.1002\/open.202400006","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T09:20:23Z","timestamp":1716369623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Concise Synthesis of (\u2212)\u2010Ambrox"],"prefix":"10.1002","volume":"13","author":[{"given":"Bingyang","family":"Wang","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Food Production and Safety Zhengzhou University of Light Industry Zhengzhou University of Light Industry  Dongfeng Road 5 Zhengzhou Henan 450002 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Food Production and Safety Zhengzhou University of Light Industry Zhengzhou University of Light Industry  Dongfeng Road 5 Zhengzhou Henan 450002 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Jia","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Food Production and Safety Zhengzhou University of Light Industry Zhengzhou University of Light Industry  Dongfeng Road 5 Zhengzhou Henan 450002 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenfang","family":"Lan","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Food Production and Safety Zhengzhou University of Light Industry Zhengzhou University of Light Industry  Dongfeng Road 5 Zhengzhou Henan 450002 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuepeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Food Production and Safety Zhengzhou University of Light Industry Zhengzhou University of Light Industry  Dongfeng Road 5 Zhengzhou Henan 450002 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-685850-1.50020-6"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19460290414"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19420250321"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19500330518"},{"key":"e_1_2_8_5_1","first-page":"34","volume":"29","author":"Chauffat C.","year":"2004","journal-title":"Perfum. 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