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This need was particularly demanding during the COVID\u201019 pandemic. While de novo drug development is a time\u2010consuming process, repurposing existing approved medications offers a more expedient approach. In our prior in silico screening of the DrugBank database, fidaxomicin emerged as a potential SARS\u2010CoV\u20102 papain\u2010like protease inhibitor. This study extends those findings by investigating fidaxomicin\u2018s antiviral properties in\u2005vitro. Our results support further exploration of fidaxomicin as a therapeutic candidate against SARS\u2010CoV\u20102, given its promising in\u2005vitro antiviral activity and favorable safety profile.<\/jats:p>","DOI":"10.1002\/open.202400091","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:39:00Z","timestamp":1722832740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SARS\u2010CoV\u20102 PL<sup>pro<\/sup> Inhibition: Evaluating in Silico Repurposed Fidaxomicin's Antiviral Activity Through In Vitro Assessment"],"prefix":"10.1002","volume":"13","author":[{"given":"Sara","family":"Proti\u0107","sequence":"first","affiliation":[{"name":"Faculty of Chemistry University of Belgrade  Studentski Trg 12\u201316 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Crnoglavac Popovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry University of Belgrade  Studentski Trg 12\u201316 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Kali\u010danin","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Technology and Metallurgy University of Belgrade  Njego\u0161eva 12 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivera","family":"Prodanovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Multidisciplinary Research University of Belgrade  Kneza Vi\u0161eslava 1 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Sen\u0107anski","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics and Computational Chemistry Institute of Nuclear Sciences Vinca National Institute of the Republic of Serbia University of Belgrade  Mike Petrovica Alasa 12\u201314 Belgrade Serbia"},{"name":"Laboratory for Plant Molecular Biology Institute of Molecular Genetics and Genetic Engineering University of Belgrade  Vojvode Stepe 444a Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Mili\u0107evi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics and Computational Chemistry Institute of Nuclear Sciences Vinca National Institute of the Republic of Serbia University of Belgrade  Mike Petrovica Alasa 12\u201314 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Stevanovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics and Computational Chemistry Institute of Nuclear Sciences Vinca National Institute of the Republic of Serbia University of Belgrade  Mike Petrovica Alasa 12\u201314 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Perovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics and Computational Chemistry Institute of Nuclear Sciences Vinca National Institute of the Republic of Serbia University of Belgrade  Mike Petrovica Alasa 12\u201314 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Paessler","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Medical Branch  Galveston Texas United States"},{"name":"Institute for Human Infections and Immunity University of Texas Medical Branch  Galveston Texas United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radivoje","family":"Prodanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry University of Belgrade  Studentski Trg 12\u201316 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Gli\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics and Computational Chemistry Institute of Nuclear Sciences Vinca National Institute of the Republic of Serbia University of Belgrade  Mike Petrovica Alasa 12\u201314 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00672-y"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01692-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00011-X"},{"key":"e_1_2_9_4_1","author":"Kozlov M.","year":"2021","journal-title":"Nature"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02657-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.03.013"},{"key":"e_1_2_9_7_1","first-page":"3","volume":"42","author":"Malik Y. 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