{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:08:51Z","timestamp":1787062131489,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21974020"],"award-info":[{"award-number":["21974020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204102"],"award-info":[{"award-number":["82204102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021\u2005J011370"],"award-info":[{"award-number":["2021\u2005J011370"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Oxidative stress caused by pregnancy\u2010induced hypertension syndrome significantly affects the health of pregnant women. Hydrogen sulfide is a typical gaseous signal molecule against oxidative stress, and it is of profound significance to develop a detection method. In this study, a stimuli\u2010responsive hydrogel was constructed based on the coordination and bonding principle of metal ions and chitosan (CS) to realize the quantitative detection of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S). The chain of CS contains a large number of amino groups and hydroxyl groups, which can form the coordination structure with Cu\n                    <jats:sup>2+<\/jats:sup>\n                    , triggering CS to form a stable hydrogel. The hydrogel can be formed within about 5\u2005s, which has the characteristics of rapid preparation. In the presence of target H\n                    <jats:sub>2<\/jats:sub>\n                    S, the cross\u2010linking agent Cu\n                    <jats:sup>2+<\/jats:sup>\n                    in the hydrogel can compete out, resulting in the collapse of the hydrogel and the release of the electrochemical probe. By detecting the concentration of the released electrochemical probe, the quantitative detection of H\n                    <jats:sub>2<\/jats:sub>\n                    S can be achieved. The prepared hydrogel has a good linear relationship with the concentration of H\n                    <jats:sub>2<\/jats:sub>\n                    S from 1\u2005\u03bcM to 60\u2005\u03bcm. At the same time, the hydrogel has good specificity and stability, and it can be applied to the detection of H\n                    <jats:sub>2<\/jats:sub>\n                    S in serum samples.\n                  <\/jats:p>","DOI":"10.1002\/open.202400107","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T16:42:59Z","timestamp":1717519379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["One\u2010Step Synthesis of Chitosan Hydrogel as Electrochemical Chemosensor for Hydrogen Sulfide Detection in Pregnancy\u2010Induced Hypertension Syndrome Serum Sample"],"prefix":"10.1002","volume":"13","author":[{"given":"Lishan","family":"Fang","sequence":"first","affiliation":[{"name":"Department of obstetrics Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Central laboratory Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Central laboratory Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of rehabilitation medicine Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liumin","family":"Yu","sequence":"additional","affiliation":[{"name":"Central laboratory Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanfei","family":"Chen","sequence":"additional","affiliation":[{"name":"Central laboratory Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Shen","sequence":"additional","affiliation":[{"name":"Central laboratory Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Central laboratory Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Central laboratory Affiliated Hospital of Putian University Putian University  Putian 351100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-6812","authenticated-orcid":false,"given":"Zhenyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology Department of Chemistry Fuzhou University  Fuzhou 350116 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113055"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2019.1668270"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6737"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121625"},{"key":"e_1_2_8_3_2","volume":"13","author":"Chen C. J.","year":"2023","journal-title":"Metabolites"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0AN00302F"},{"key":"e_1_2_8_4_2","volume":"20","author":"Chen T. 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