{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:48:56Z","timestamp":1792432136957,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetes is a chronic metabolic disorder affecting about 463\u2005million people globally. \u03b1\u2010Glucosidase (EC.3.2.1.20) inhibitors are among the FDA\u2010approved oral anti\u2010diabetic medications used to treat type\u20052 diabetes. In search of new potential \u03b1\u2010glucosidase inhibitors, fifteen of our previously synthesized hydantoin derivatives\n                    <jats:bold>8\u2009a<\/jats:bold>\n                    \u2013\n                    <jats:bold>o<\/jats:bold>\n                    were evaluated for their antidiabetic activity. All compounds\n                    <jats:bold>8\u2009a<\/jats:bold>\n                    \u2013\n                    <jats:bold>o<\/jats:bold>\n                    showed weak \u03b1\u2010glucosidase inhibition at 10, 50 and 100\u2005\u03bcM. However, at 200\u2005\u03bcM, compound\n                    <jats:bold>8\u2009o<\/jats:bold>\n                    was the most potent among the series followed by compounds\n                    <jats:bold>8\u2009a, 8\u2009d, 8\u2009l<\/jats:bold>\n                    and\n                    <jats:bold>8\u2009n<\/jats:bold>\n                    exhibiting moderate inhibition. The established SAR depended upon the exchange of methyl with methoxy and dioxole derivatives at positions 3 and 4 of the phenyl ring. Cytotoxicity studies revealed that most of the compounds have no cytotoxic effect. Furthermore, Swiss ADME predictions of compounds\n                    <jats:bold>8\u2009a<\/jats:bold>\n                    ,\n                    <jats:bold>8\u2009d<\/jats:bold>\n                    ,\n                    <jats:bold>8\u2009i<\/jats:bold>\n                    ,\n                    <jats:bold>8\u2009l<\/jats:bold>\n                    and\n                    <jats:bold>8\u2009o<\/jats:bold>\n                    showed high gastrointestinal intestinal absorption required for intestinal absorption of any drug. Most compounds did not obey drug\u2010likeness character since they violated Ghose and Veber rules with MW&gt;350 and rotors&gt;11. Molecular docking was carried out to investigate the binding interaction of compounds with the active site of \u03b1\u2010glucosidase. The results correlated well with those of the experimental, thereby contributing towards the development of new \u03b1\u2010glucosidase inhibitors.\n                  <\/jats:p>","DOI":"10.1002\/open.202400119","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T01:20:27Z","timestamp":1738632027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>In\u2005vitro<\/i>\n                    \u03b1\u2013Glucosidase Inhibition, Cytotoxicity, SAR, Swiss ADME Prediction and Molecular Docking Study of New\n                    <i>N<\/i>\n                    \u2013Substituted Hydantoin Derivatives"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-247X","authenticated-orcid":false,"given":"Ndivhuwo R.","family":"Tshiluka","sequence":"first","affiliation":[{"name":"Research Centre for Synthesis and Catalysis Department of Chemical Sciences University of Johannesburg  Kingsway Campus, P.O. Auckland Park 2006 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakalo T.","family":"Mbedzi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology University of Venda  Private Bag X5050 Thohoyandou South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mpelegeng V.","family":"Bvumbi","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Venda  Private Bag X5050 Thohoyandou South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon S.","family":"Mnyakeni\u2010Moleele","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Venda  Private Bag X5050 Thohoyandou South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Diabetes Care2009 32 Supp 1 62\u201367.","DOI":"10.2337\/dc09-S062"},{"key":"e_1_2_8_2_1","first-page":"1","volume":"12","author":"Huang T.","year":"2022","journal-title":"Front. 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