{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:28:27Z","timestamp":1780540107423,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"publisher","award":["VAST03.03\/22-23"],"award-info":[{"award-number":["VAST03.03\/22-23"]}],"id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The combination of natural polymers and plant extract attracted much attention thanks to its valuable biological activities. This study presents the preparation and characterization of chitosan (CS) film containing\n                    <jats:italic>Rhodomyrtus tomentosa<\/jats:italic>\n                    leaf extract. In which, the\n                    <jats:italic>Rhodomyrtus tomentosa<\/jats:italic>\n                    leaf extract (SLE) with polyphenol\u2010rich fractions was extracted by an ultrasonic\u2010assisted extraction method. The prepared chitosan\/polyphenol\u2010rich fractions film (CSPPF) was characterized using infrared (IR) spectroscopy, mechanical testing, scanning electron microscopy (SEM), and water absorption analysis. Antibacterial and anti\u2010inflammatory activities of the CSPPF were assessed using the agar well diffusion method and nitric oxide (NO) inhibition assays, respectively. Besides, the release of the extract from the CSPPF as well as the drug release kinetics was also tested. The\n                    <jats:italic>Rhodomyrtus tomentosa<\/jats:italic>\n                    leaf extract enhanced the antibacterial efficacy against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and enhanced the anti\u2010inflammatory activity as well as the swelling ability of the CSPPF. The CSPPF containing 1\u2005wt.% of SLE can inhibit 77.70\u2009% NO with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 19.40\u2005\u03bcg\/mL.\n                  <\/jats:p>","DOI":"10.1002\/open.202400302","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T23:06:23Z","timestamp":1732316783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antibacterial and Anti\u2010Inflammatory Activity of Chitosan Film with\n                    <i>Rhodomyrtus Tomentosa<\/i>\n                    Leaf Extract Prepared Via 3D\u2010Printing Method"],"prefix":"10.1002","volume":"14","author":[{"given":"Quan","family":"Vo\u2010An","sequence":"first","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-3835","authenticated-orcid":false,"given":"Chinh Thuy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uyen Thu","family":"Pham","sequence":"additional","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-7693","authenticated-orcid":false,"given":"Tuan Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"},{"name":"University Science and Technology Hanoi Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-9455","authenticated-orcid":false,"given":"Dung Tran","family":"Hoang","sequence":"additional","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu Trong","family":"Le","sequence":"additional","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quyen Thi Cam","family":"Ngo","sequence":"additional","affiliation":[{"name":"Institute of Environmental Sciences Nguyen Tat Thanh University  300A Nguyen Tat Thanh, Ward 13, District 4 Ho Chi Minh City 700000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-6194","authenticated-orcid":false,"given":"Hoang","family":"Thai","sequence":"additional","affiliation":[{"name":"Institute for Tropical Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Nghia Do, Cau Giay Hanoi 100000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117768"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.04.043"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.113"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00896F"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-019-01550-8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.15625\/2525-2518\/56\/3B\/12716"},{"key":"e_1_2_12_7_1","first-page":"7","volume":"1","author":"Tran D. 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