{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:33:05Z","timestamp":1787639585201,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Molecular hybrids of diversely functionalized quinoline and sulfonamide have been designed. Multistep synthetic strategies have been used for the synthesis. The anti\u2010cancer properties have been evaluated against various cancer cell lines including HCT116, A549, U2OS, CCRF\u2010CEM, Jurkat, MOLT\u20104, RAMOS, and K562. Non\u2010cancer cell lines MRC\u20105 and BJ were also included for comparison. When examining the effects on A549, HCT116, and U2OS cells, all tested compounds exhibited limited potency with IC<jats:sub>50<\/jats:sub> values exceeding 50\u2005\u03bcM, indicating weak activity against these cell lines. Against the ITK high cells <jats:italic>Viz<\/jats:italic>. are Jurkat, CCRF\u2010CEM and MOLT\u20104, <jats:bold>9\u2009e, 9\u2009p<\/jats:bold> and <jats:bold>9\u2009j<\/jats:bold> found to the maximum potent compounds with IC<jats:sub>50<\/jats:sub> values of 7.43\u00b17.40\u2005\u03bcM, 13.19\u00b11.25\u2005\u03bcM and 5.57\u00b17.56\u2005\u03bcM respectively. Similarly, in the BTK high cells screenings, <jats:bold>9\u2009n<\/jats:bold> and <jats:bold>9\u2009e<\/jats:bold> molecules with an IC<jats:sub>50<\/jats:sub> value of 2.76\u00b10.79\u2005\u03bcM and 5.47\u00b11.71\u2005\u03bcM against RAMOS and K562 respectively are highly potent. Interestingly, all the molecules have exhibited IC<jats:sub>50<\/jats:sub> value &gt;50\u2005\u03bcM against the non\u2010cancer cells (MRC\u20105 and BJ), which indicates the promising non\u2010cytotoxic nature of the molecules.<\/jats:p>","DOI":"10.1002\/open.202400334","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T01:03:30Z","timestamp":1732669410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and <i>in Vitro<\/i> Anticancer Studies"],"prefix":"10.1002","volume":"14","author":[{"given":"Padyala","family":"Panduranga","sequence":"first","affiliation":[{"name":"Department of Chemistry VFSTR (Deemed to be University)  Vadlamudi, Guntur, Andhra Pradesh 522213 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parameshwar","family":"Makam","sequence":"additional","affiliation":[{"name":"Division of Research and Innovation Department of Chemistry Uttaranchal University,Arcadia Grant, P.O. Chandanwari  Premnagar, Dehradun Uttarakhand 248007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-8528","authenticated-orcid":false,"given":"Naresh","family":"Kumar Katari","sequence":"additional","affiliation":[{"name":"School of Chemistry &amp; Physics College of Agriculture Engineering &amp; Science Westville Campus University of KwaZulu-Natal  P Bag X 54001 Durban 4000 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rambabu","family":"Gundla","sequence":"additional","affiliation":[{"name":"Department of Chemistry GITAM School of Science GITAM Deemed to be University  Hyderabad, Telangana 502329 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekantha","family":"Babu Jonnalagadda","sequence":"additional","affiliation":[{"name":"School of Chemistry &amp; Physics College of Agriculture Engineering &amp; Science Westville Campus University of KwaZulu-Natal  P Bag X 54001 Durban 4000 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Kumar Tripuramallu","sequence":"additional","affiliation":[{"name":"Department of Chemistry VFSTR (Deemed to be University)  Vadlamudi, Guntur, Andhra Pradesh 522213 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-00292-x"},{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","unstructured":"J. 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