{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:19:15Z","timestamp":1789438755203,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigates the antioxidant, antimicrobial, and anticancer properties of <jats:italic>Pancratium maritimum<\/jats:italic> L. in Sp. Pl.: 291 (1753) seeds and flowers. Antioxidant activity was assessed using DPPH free radical scavenging and iron chelation assays. Antimicrobial evaluations assessed the efficacy of the extracts against diverse microorganisms. Cell viability assays were conducted on the dukes c colon cancer (SW480), while gas chromatography\u2010mass spectrometry (GC\u2010MS) analysis facilitated the identification of bioactive compounds. The ethanol extract of <jats:italic>P. maritimum<\/jats:italic> seeds exhibited a total phenolic content of 296.89\u00b114.53\u2005mg GAE\/g extract DW and a total flavonoid content of 361.03\u00b120.18\u2005mg QE\/g extract DW. Conversely, the flower extract showed a total phenolic content of 95.03\u00b17.22\u2005mg GAE\/g extract DW and a total flavonoid content of 272.12\u00b116.42\u2005mg QE\/g extract DW. As a result, the ethanol extract of <jats:italic>P. maritimum<\/jats:italic> seeds contains higher phenolic and flavonoid contents than the flower extract. Antimicrobial evaluations demonstrated significant inhibitory effects of both seed and flower extracts, with minimum inhibitory concentration (MIC) values ranging from 25 to &gt;50\u2005mg\/mL. Notably, the seed extract showed greater activity against <jats:italic>E. coli<\/jats:italic> and <jats:italic>C. krusei<\/jats:italic>. GC\u2010MS analysis identified 18 bioactive compounds in the seed extract and 16 in the flower extract, with crucial components including ethyl oleate and 5\u2010hydroxymethylfurfural. Additionally, cell viability assays revealed that ethanol extracts from seeds and flowers significantly reduced SW480\u2005cell viability, particularly at doses of 750\u2005\u03bcg\/mL and 250\u2005\u03bcg\/mL, respectively. These findings underscore the therapeutic potential of <jats:italic>P. maritimum<\/jats:italic> in terms of its antioxidant, antimicrobial, and anticancer properties, highlighting its value as a natural source of antioxidants and antimicrobial agents. Furthermore, the molecular docking study emphasises strong binding interactions of key compounds, particularly ethyl oleate and hexadecanoic acid ethyl ester, with the human STARD10 protein. The biological interactions and health implications of <jats:italic>P. maritimum<\/jats:italic> provide a significant foundation for future research in drug development and therapeutic applications.<\/jats:p>","DOI":"10.1002\/open.202400407","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T03:46:38Z","timestamp":1736480798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antioxidant, Antimicrobial, Anticancer, and Molecular Docking Insights into <i>Pancratium maritimum<\/i> Seeds and Flowers: A Phytochemical Approach"],"prefix":"10.1002","volume":"14","author":[{"given":"Muhammed","family":"Sait Ertu\u011frul","sequence":"first","affiliation":[{"name":"Hemp Research Institute Ondokuz May\u0131s University  Samsun 55200 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Balp\u0131nar","sequence":"additional","affiliation":[{"name":"Hemp Research Institute Ondokuz May\u0131s University  Samsun 55200 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0183","authenticated-orcid":false,"given":"Erdi","family":"Can Aytar","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Department of Horticulture Usak University  U\u015fak 64200 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Biology Gazi University  Ankara 06500 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Incilay Torunoglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Biochemistry Necmettin Erbakan University  Konya 42090 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Ali Nihat G\u00f6kyi\u011fit Botanical Garden Application and Research Center Artvin \u00c7oruh University  08000 Artvin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altevir","family":"Rossato Viana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Federal University of Santa Maria  Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00046"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-019-00349-z"},{"key":"e_1_2_9_3_1","unstructured":"POWO \u201cPancratium Dill. ex L.|Plants of the World Online | Kew Science \u201d can be found underhttps:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:327251-2 2024."},{"key":"e_1_2_9_4_1","unstructured":"POWO \u201cPancratium maritimum L.|Plants of the World Online|Kew Science \u201d can be found underhttps:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:66466-1 2024."},{"key":"e_1_2_9_5_1","unstructured":"P.\u2005H. 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