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The general synthesis of these compounds began with an L\u2010proline\u2010mediated three\u2010component Mannich reaction between commercially available 3\u2010fluoro\u20104\u2010morpholinoaniline, aqueous formaldehyde and \u03b1\u2010hydroxyacetone. This was followed by a one\u2010step cyclisation to form the core structure of oxazolidinone antibiotics which was subsequently derivatized. The novel compounds were evaluated for their antibacterial activity against\n                    <jats:italic>M. smegmatis<\/jats:italic>\n                    . One of the novel oxazolidinone derivatives\n                    <jats:bold>18\u2009a1<\/jats:bold>\n                    produced a MIC of 8\u2005mg\/L, comparable with the commercial Rifampicin. The methodology is a useful addition to the field since it can make highly sought\u2010after oxazolidinone derivatives, using cheaper, less harsh commercially available reagents, in a short time and one pot.\n                  <\/jats:p>","DOI":"10.1002\/open.202400432","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T02:02:03Z","timestamp":1736301723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents"],"prefix":"10.1002","volume":"14","author":[{"given":"Secret P.","family":"Els","sequence":"first","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberleigh B.","family":"Govender","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mxolisi K.","family":"Sokhela","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilay","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-2241","authenticated-orcid":false,"given":"Nakita","family":"Reddy","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0606-2053","authenticated-orcid":false,"given":"Hendrik G.","family":"Kruger","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-6812","authenticated-orcid":false,"given":"Per I.","family":"Arvidsson","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"},{"name":"Science for Life Laboratory Drug Discovery &amp; Development Platform and Division of Translational Medicine and Chemical Biology Department of Medical Biochemistry and Biophysics Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3897-1948","authenticated-orcid":false,"given":"Hendra","family":"Gunosewoyo","sequence":"additional","affiliation":[{"name":"Curtin Medical School, Faculty of Health Sciences Curtin University  Bentley, Perth WA 6102 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-2503","authenticated-orcid":false,"given":"Thavendran","family":"Govender","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zululand, Private Bag X1001  KwaDlangezwa 3886 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-6258","authenticated-orcid":false,"given":"Tricia","family":"Naicker","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences Catalysis and Peptide Research Unit University of KwaZulu-Natal  Durban 4000 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00359-7"},{"key":"e_1_2_8_2_1","volume-title":"Global tuberculosis report 2023","author":"Organization W. 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