{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:28:11Z","timestamp":1790303291166,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:italic>Phlomis<\/jats:italic>\n                    species (family Lamiaceae) are highly valued as food and herbal medicine. The present study is designed to investigate the chemical composition and antioxidant and enzyme inhibitory activities of extracts from\n                    <jats:italic>P. fruticosa,<\/jats:italic>\n                    <jats:italic>P. herba\u2010venti,<\/jats:italic>\n                    and\n                    <jats:italic>P. kurdica<\/jats:italic>\n                    aerial parts. Different classes of metabolites, including phenolic acids, phenylethanoids, flavonoids, iridoids, organic acids, terpenes, and fatty acids, are identified in the three species, with methanol as the best solvent to recover bioactive compounds from the three species in addition to ethyl acetate for\n                    <jats:italic>P. kurdica<\/jats:italic>\n                    . Around 70% methanol extract of\n                    <jats:italic>P. herba\u2010venti<\/jats:italic>\n                    exerts the best radical scavenging and ions\u2010reducing properties, while its methanol extract exhibits the highest acetylcholinesterase inhibitory activity. The ethyl acetate extract of\n                    <jats:italic>P. fruticosa<\/jats:italic>\n                    displays the best chelating power, and its other polar extracts have the highest total antioxidant activity. Furthermore, molecular docking and molecular dynamics simulations have underscored the therapeutic potential of bioactive compounds, including isoverbascoside, samioside, forsythoside B, and hattushoside. In conclusion, the study indicates that these three\n                    <jats:italic>Phlomis<\/jats:italic>\n                    species are a rich source of bioactive molecules with possible therapeutic applications, and the selection of appropriate extraction solvents is crucial for the targeted biological activity.\n                  <\/jats:p>","DOI":"10.1002\/open.202500004","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T03:24:58Z","timestamp":1747020298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Chemical Characterization, Antioxidant and Enzyme\u2010Inhibitory Activities of Different Extracts from Three\n                    <i>Phlomis<\/i>\n                    Species"],"prefix":"10.1002","volume":"14","author":[{"given":"Sakina","family":"Yagi","sequence":"first","affiliation":[{"name":"Department of Botany Faculty of Science University of Khartoum  Khartoum 11115 Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty Selcuk University  42130 Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Veysi","family":"Cetiz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine Harran University  63290 Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Czi\u00e1ky","sequence":"additional","affiliation":[{"name":"Agricultural and Molecular Research and Service Institute University of Ny\u00edregyh\u00e1za  001 Ny\u00edregyh\u00e1za HU\u20104400 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Jeko","sequence":"additional","affiliation":[{"name":"Agricultural 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