{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:07:23Z","timestamp":1790161643314,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    <jats:italic>Fibigia clypeata<\/jats:italic>\n                    (L.) Medik, a member of the Brassicaceae, has been the subject of limited research on its pharmaceutical and medicinal properties. This study aims to evaluate the phytochemical, antimicrobial, and antimyeloma properties of\n                    <jats:italic>F. clypeata<\/jats:italic>\n                    extracts and detail these results in silico analyses. The minimum inhibitory concentration (MIC) of\n                    <jats:italic>F. clypeata<\/jats:italic>\n                    extracts was determined using dilution methods, and antimyeloma activity was determined using an MTT (3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u22122,5\u2010diphenyl\u20102H\u2010tetrazolium bromide) assay. The findings were evaluated by in silico analyses and correlated with the results of liquid chromatography\u2010high\u2010resolution mass spectrometry. The inhibitory effect of the water extract (MIC is 15\u2009mg\u2009mL\n                    <jats:sup>\u20101<\/jats:sup>\n                    against bacterial strains; MICs are between 7.5 and 3.75\u2009mg\u2009mL\n                    <jats:sup>\u20101<\/jats:sup>\n                    against\n                    <jats:italic>Candida<\/jats:italic>\n                    strains) was determined to be more potent than methanol extract (MIC is 60\u2009mg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    against bacterial strains; MICs are between 30\u2009mg\/mL and 7.50\u2009mg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    against\n                    <jats:italic>Candida<\/jats:italic>\n                    strains). Molecular docking findings revealed that cyanidin 3\u2010rutinoside chloride showed the highest binding affinity to\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    MurB,\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    , and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    dihydrofolate reductases and the antitumor target human epidermal growth factor receptor protein. Based on MTT results,\n                    <jats:italic>F. clypeata<\/jats:italic>\n                    extracts significantly decreased cell viability dose\u2010dependently in three human MM and noncancerous MCF10A cell lines.\n                    <jats:italic>F. clypeata<\/jats:italic>\n                    harbor valuable antimicrobial and moderately anticancerogenic compounds.\n                  <\/jats:p>","DOI":"10.1002\/open.202500036","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:55:41Z","timestamp":1756972541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multidirectional in silico and in vitro Research for the Pharmaceutical Potential of Fibigia Clypeata (L.) Medik: Phytochemical, Antimicrobial, and Antimyeloma Properties"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-2716","authenticated-orcid":false,"given":"Tuba","family":"Unver","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Microbiology Faculty of Pharmacy Inonu University  44280 Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-3730","authenticated-orcid":false,"given":"Ugur","family":"Uzuner","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Faculty of Science Karadeniz Technical University  61080 Trabzon Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2586-4385","authenticated-orcid":false,"given":"Dilara","family":"Akcora\u2010Yildiz","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science &amp; Art Mehmet Akif Ersoy University  15200 Burdur Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-2447","authenticated-orcid":false,"given":"Ismet","family":"Gurhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Inonu University  44280 Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5367-0248","authenticated-orcid":false,"given":"Caglar","family":"Arkan","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science &amp; Art Mehmet Akif Ersoy University  15200 Burdur Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-2305","authenticated-orcid":false,"given":"Zeynep","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Inonu University  44280 Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401208"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4341"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2024.104832"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods9040457"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.102293"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981543"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0108462"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods9060705"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.17221\/132\/2010-CJFS"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75499-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0575-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25791"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04404-3"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1118761"},{"key":"e_1_2_10_16_1","volume-title":"Flora of Turkey and the East Aegean Islands","author":"Matthews V. 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