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First, an ibuprofen (IBU)\u2010functionalized methacrylate (TBMA\u2010IBU) is synthesized from the reaction of\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butyl\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010bromomethacrylate with IBU. The free radical homopolymerization and copolymerization with poly(ethylene glycol) methyl ether methacrylate (\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>n<\/jats:sub>\n                    \u2009=\u2009300), cleavage of\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butyl ester groups of the homopolymer and a copolymer with trifluoroacetic acid (TFA) gave new polymer prodrugs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010TBMA\u2010IBU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010TBMA\u2010IBU\n                    <jats:italic>\u2010co<\/jats:italic>\n                    \u2010PEGMA,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010MA\u2010IBU, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010MA\u2010IBU\n                    <jats:italic>\u2010co<\/jats:italic>\n                    \u2010PEGMA), with IBU linked through ester bonds on the side chain. The release studies showed extended\u2010release of IBU (20\u201360% in 15\u2009d), which can be triggered under the stimulation of lipase. The in\u2009vitro studies indicate that the representative polymers are effective in relieving inflammatory responses in RAW264.7 macrophage cells without any cytotoxicity. These results suggest that the synthesized polymers with controllable functionality can be promising IBU prodrugs.\n                  <\/jats:p>","DOI":"10.1002\/open.202500038","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:39:38Z","timestamp":1749037178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ibuprofen\u2010Functionalized Alkyl\n                    <i>\u03b1<\/i>\n                    \u2010hydroxy Methacrylate\u2010Based Polymers"],"prefix":"10.1002","volume":"14","author":[{"given":"Burcu","family":"Balaban","sequence":"first","affiliation":[{"name":"Department of Chemistry Bogazici University  Bebek 34342 Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seckin","family":"Altuncu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Bogazici University  Bebek 34342 Istanbul 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