{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:19:07Z","timestamp":1792113547195,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Medicinal plants possess the potential to yield bioactive compounds that offer significant health benefits; positioning them as valuable and promising sources for the development of innovative pharmaceutical products. This study aims to comprehensively assess the\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    and\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    pharmacological effects of the aqueous extract of the plant\n                    <jats:italic>Atractylis aristata<\/jats:italic>\n                    (AEAA) as well as assessments of its phytochemical composition. UPLC\u2010ESI\u2010MS\/MS analysis of AEAA revealed a variety of bioactive compounds, including flavonoids and phenolic acids. In antioxidant assays, AEAA demonstrated considerable activity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.269\u00b10.05\u2005mg\/mL for DPPH scavenging and 0.0376\u00b10.003\u2005mg\/mL for hydrogen peroxide radical inhibition. AEAA exhibited strong anti\u2010inflammatory activity\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    , with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 2.563\u2005mg\/mL in the BSA denaturation test.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , AEAA reduced carrageenan\u2010induced paw edema by 56.51\u2009%, in comparison to an 83.58\u2009% reduction with Ibuprofen\u00ae. Antibacterial testing showed AEAA\u2032s broad\u2010spectrum activity, with the highest inhibition against\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    (34\u2005mm zone of inhibition). Additionally, AEAA induced significant sedative effects, reducing locomotor activity by 48.98\u2009%. These findings underscore the diverse pharmacological potential in addressing oxidative stress, inflammation, microbial infections, and anxiety of\n                    <jats:italic>A. aristata<\/jats:italic>\n                    , which can be attributed to its rich phytochemical profile.\n                  <\/jats:p>","DOI":"10.1002\/open.202500056","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:21:32Z","timestamp":1744885292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unveiling the Therapeutic Potential of\n                    <i>Atractylis aristata<\/i>\n                    Batt. Aqueous Extract: Anti\u2010inflammatory, Antioxidant, Antibacterial, Sedative Activities &amp; Phytochemical Profiling"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-566X","authenticated-orcid":false,"given":"Asma","family":"Abid","sequence":"first","affiliation":[{"name":"Laboratory of Valorization and Promotion of Saharan Resources Faculty of Mathematics and Matter Sciences University of Ouargla  Road of Ghardaia 30000 Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourelhouda","family":"Mekhadmi","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Nature and Life Sciences University of El Oued  39000 El Oued Algeria"},{"name":"Laboratory of the Development and Technology of Saharan Resources (VTRS) Echahid Hamma Lakhdar El Oued University  Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"Mlik","sequence":"additional","affiliation":[{"name":"National Institute of Agronomic Research of Algeria  INRAA, P. O. Box 299, Station of Adrar Adrar Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Bentahar","sequence":"additional","affiliation":[{"name":"Laboratory of Phytotherapy Applied to Chronic Diseases SNV Faculty University of Setif 1  19000 S\u00e9tif Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilia","family":"Bireche","sequence":"additional","affiliation":[{"name":"Laboratory of Valorization and Promotion of Saharan Resources Faculty of Mathematics and Matter Sciences University of Ouargla  Road of Ghardaia 30000 Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bariza","family":"Frih","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Nature and Life Sciences University of El Oued  39000 El Oued Algeria"},{"name":"Laboratory of the Development and Technology of Saharan Resources (VTRS) Echahid Hamma Lakhdar El Oued University  Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Boussebaa","sequence":"additional","affiliation":[{"name":"Scientific and Technical Research Center in Physico-Chemical Analysis (CRAPC)  Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicha","family":"Mouane","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Nature and Life Sciences University of El Oued  39000 El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nezar","family":"Cherrada","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Nature and Life Sciences University of El Oued  39000 El Oued Algeria"},{"name":"Laboratory of Biodiversity and Application of Biotechnology in Agriculture University of El Oued, El-Oued  Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sanches Silva","sequence":"additional","affiliation":[{"name":"University of Coimbra Faculty of Pharmacy  Coimbra 3000-548 Coimbra Portugal"},{"name":"Centre for Animal Science Studies (CECA), ICETA  4099-002 Porto Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences  1300-477 Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messaouda","family":"Dekmouche","sequence":"additional","affiliation":[{"name":"Laboratory of Valorization and Promotion of Saharan Resources Faculty of Mathematics and Matter Sciences University of Ouargla  Road of Ghardaia 30000 Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazhar","family":"Bechki","sequence":"additional","affiliation":[{"name":"Laboratory of Valorization and Promotion of Saharan Resources Faculty of Mathematics and Matter Sciences University of Ouargla  Road of Ghardaia 30000 Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Mashay","family":"Al\u2010Anazi","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh 11451 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Abul","family":"Farah","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh 11451 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Mumbai, Vidyanagari  Mumbai 400098"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000996"},{"key":"e_1_2_9_2_1","author":"Gandhi G. R.","year":"2023","journal-title":"Journal of Pharmaceutical Analysis."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010095"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1158198"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.33192\/smj.v76i8.268647"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304413"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1425485"},{"key":"e_1_2_9_8_1","author":"Mitra S. K.","year":"2008","journal-title":"Natural sedative composition, process for obtaining the same and pharmaceutical formulations thereof"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejvs.2019.12613.1078"},{"key":"e_1_2_9_10_1","first-page":"158","volume":"15","author":"Timotius K. H.","year":"2023","journal-title":"Pimpinella pruatjan Molk: LC\u2013MS\/MS-QTFT Analysis of Bioactive Compounds from Decoction and Ethanol Extract of Aerial Parts."},{"key":"e_1_2_9_11_1","author":"Taskin T.","year":"2020","journal-title":"Investigation of the Biological Activities of Different Extracts from Dipsacus laciniatus Aerial"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-021-00358-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.14719\/pst.2018.5.3.393"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118252"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974-360X.2022.00564"},{"key":"e_1_2_9_16_1","first-page":"152","volume-title":"[14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. In Methods in enzymology","author":"Singleton V. L.","year":"1999"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.1820"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/chem-2024-0087"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19970800411"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-024-02769-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.11.063"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.15586\/ijfs.v36i3.2627"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573407216666200109120431"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/23311932.2024.2328429"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-023-03221-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-024-03585-1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-024-04606-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-374-7:115"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)21892-4"},{"key":"e_1_2_9_30_1","first-page":"6697","volume":"5","author":"Ghasemzadeh A.","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2016.09.011"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111017"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113041"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1699014"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17080975"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(01)00402-2"},{"key":"e_1_2_9_37_1","author":"Azlina M.","year":"2012","journal-title":"International Food Research Journal (Malaysia)"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.12096"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15101202"},{"key":"e_1_2_9_40_1","first-page":"35","volume":"1","author":"Asif M.","year":"2015","journal-title":"Chem. Int."},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02689-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2020.03.042"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041619"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8010016"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2016.05.003"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12266"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB11.007"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","DOI":"10.4081\/jbr.2023.11096","volume":"96","author":"Mouffouk S.","year":"2023","journal-title":"Journal of Biological Research-Bollettino della Societ\u00e0 Italiana di Biologia Sperimentale"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00345-7"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165712"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061283"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15122673"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191219292"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.3.597"},{"key":"e_1_2_9_55_1","volume":"57","author":"Williams L.","year":"2008","journal-title":"West Indian Med. J."},{"key":"e_1_2_9_56_1","author":"Bagad Y.","year":"2011","journal-title":"Investigation of anti-inflammatory and analgesic activity of Bridelia airyshawii (Euphorbiaceae)"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2018.4.128"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112640"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113415"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12223860"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/2421"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155251"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.11.028"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27082414"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1300-y"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.86"}],"container-title":["ChemistryOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.202500056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/open.202500056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.202500056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:59:49Z","timestamp":1778752789000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/open.202500056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":66,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/open.202500056"],"URL":"https:\/\/doi.org\/10.1002\/open.202500056","archive":["Portico"],"relation":{},"ISSN":["2191-1363","2191-1363"],"issn-type":[{"value":"2191-1363","type":"print"},{"value":"2191-1363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2025-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500056"}}