{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:04:08Z","timestamp":1784225048151,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    In this study, two new 2,2\u2032\u2010bipyridine\u20104,4\u2032\u2010dicarboxamide ligands, namely N4,N4\u2032\u2010bis(pyridin\u20102\u2010ylmethyl)\u2010[2,2\u2032\u2010bipyridine]\u20104,4\u2032\u2010dicarboxamide (\n                    <jats:bold>L1<\/jats:bold>\n                    ) and N4,N4\u2032\u2010bis(piperidin\u20102\u2010ylmethyl)\u2010[2,2\u2032\u2010bipyridine]\u20104,4\u2032\u2010dicarboxamide (\n                    <jats:bold>L2<\/jats:bold>\n                    ), and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. Elemental analysis, Fourier transform infrared spectroscopy, nuclear magnetic resonance, and mass techniques confirmed the structures of the synthesized compounds. The\n                    <jats:bold>L1<\/jats:bold>\n                    structure is also determined by single\u2010crystal X\u2010ray diffraction. Antibacterial activities of ligands and metal complexes against resistant strains are investigated. The\n                    <jats:bold>L2\u2010Co<\/jats:bold>\n                    complex demonstrates promising antibacterial qualities against these resistant strains, which is noteworthy. Additionally, enzyme inhibition studies are conducted to assess their potential therapeutic applications. The results show that the\n                    <jats:bold>L2\u2010Ni<\/jats:bold>\n                    complex had the strongest inhibitory effect with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 1.35 \u03bcM for lipase enzyme, 4.33 \u03bcM for acetylcholinesterase enzyme, and 6.42 \u03bcM for butyrylcholinesterase.\n                  <\/jats:p>","DOI":"10.1002\/open.202500097","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T11:08:53Z","timestamp":1749467333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2\u2032\u2010Bipyridine\u20104,4\u2032\u2010Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition"],"prefix":"10.1002","volume":"14","author":[{"given":"Hussein","family":"Alchurak","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy University of Kufa  Najaf 540011 Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel","family":"Almadhoun","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology The Institute of Graduate Programs Karab\u00fck University  Karab\u00fck 78050 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-0122","authenticated-orcid":false,"given":"\u0130smail","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences Karab\u00fck University  Karab\u00fck 78050 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raneem Mamoun","family":"Ali Nour","sequence":"additional","affiliation":[{"name":"Department of Food Toxicology The Institute of Graduate Programs Karab\u00fck University  Karab\u00fck 78050 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcsl\u00fcm","family":"Kuzu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences Karab\u00fck University  Karab\u00fck 78050 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Solmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine Karab\u00fck University  Karab\u00fck 78050 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2010.512385"},{"key":"e_1_2_8_3_1","first-page":"781","volume":"34","author":"A\u011fa\u00e7 \u00c7.","year":"2010","journal-title":"Turkish J. 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