{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:24:03Z","timestamp":1780644243163,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    This research is designed to investigate the sedative effects of naringenin (NAR) and diazepam against thiopental sodium\u2010induced sleeping mice. NAR (5 and 10\u2009mg\u2009kg), diazepam (DZP) (2\u2009mg\u2009kg), flumazenil (FLN) (0.1\u2009mg\u2009kg), and their combinations are administered intraperitoneally to mice. After 30\u2009min, sleep is induced with intraperitoneal thiopental sodium (20\u2009mg\u2009kg), and sleep latency and duration are measured. In silico analysis investigates the role of GABA receptors. NAR significantly reduces sleep latency and prolongs sleep duration in a dose\u2010dependent manner, with the combination of NAR\u201010 and DZP\u20102 showing a synergistic effect. The combination of the antagonist (FLN) (NAR\u201010 and FLN\u20100.1) indicates that latency increases and sleep duration decreases compared to NAR\u201010 alone. Furthermore, in silico docking studies corroborates these results, demonstrating a significant binding affinity of NAR (\u22128.3\u2009kcal\u2009mol), which is comparable to the standard ligand DZP (\u22128.7\u2009kcal\u2009mol) and FLN (\u22127.0\u2009kcal\u2009mol) for the GABA\n                    <jats:sub>A<\/jats:sub>\n                    (6X3X) receptor, indicating a GABAergic mechanism. Pharmacokinetics and toxicity evaluations confirm NAR's potential as a safe therapeutic agent, with a high LD50 (2000\u2009mg\u2009kg) and minimal toxicity. These findings highlight NAR's potential as a GABAergic sedative agent, requiring further research before being used clinically to treat sleep disorders.\n                  <\/jats:p>","DOI":"10.1002\/open.202500114","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T22:35:44Z","timestamp":1749422144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights"],"prefix":"10.1002","volume":"14","author":[{"given":"Dipu","family":"Bishwas","sequence":"first","affiliation":[{"name":"Department of Pharmacy Pabna University of Science and Technology  Pabna 6600 Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory Bioluster Research Center Ltd.  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