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Due to resistance phenomena, the last decade has seen a significant challenge for candidiasis treatment with antifungal drugs, which has led to an urgent need for new antifungal agents. In this article, we report the synthesis of a series of azomethine\u2010pyrazole derivatives bearing a\n                    <jats:italic>para<\/jats:italic>\n                    \u2010substituted azo\u2010phenyl ring. These compounds were evaluated as antifungal agents against\n                    <jats:italic>Candida<\/jats:italic>\n                    species and\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    strains. Compound\n                    <jats:bold>ClAzoNH<\/jats:bold>\n                    , substituted by chloride, displayed the highest toxicity on\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , with an MIC\n                    <jats:sub>50<\/jats:sub>\n                    value of 2.08 \u03bcg\/mL, while methoxy\u2010substituted\n                    <jats:bold>MeOAzoNH<\/jats:bold>\n                    showed moderate inhibitory activity. The unsubstituted\n                    <jats:bold>AzoNH<\/jats:bold>\n                    compound exhibited the highest activity towards\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    ,\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    ,\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    , and\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    strains. In the case of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , the\n                    <jats:italic>Ca<\/jats:italic>\n                    CYP51 protein appears to be the most probable biological target, while for\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    , interactions with the\n                    <jats:italic>Cn<\/jats:italic>\n                    FTase protein explained the\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    results.\n                  <\/jats:p>","DOI":"10.1002\/open.202500132","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:56:34Z","timestamp":1745888194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the Antifungal Properties of Azomethine\u2010Pyrazole Derivatives from a Structural 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