{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:13:33Z","timestamp":1785287613323,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    This study investigates the antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities of\n                    <jats:italic>Arenaria serpyllifolia<\/jats:italic>\n                    extract. A methanolic extract from the plant's above\u2010ground parts is prepared via maceration. The extract exhibits strong antioxidant properties (DPPH IC\n                    <jats:sub>50<\/jats:sub>\n                    : 355.54\u2009\u00b1\u200920.62\u2009\u03bcg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and iron chelating ability (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 5.30\u2009\u00b1\u20094.44\u2009mg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Total flavonoid and phenolic contents are 75.15\u2009\u00b1\u20092.73\u2009mg quercetin equivalent\u2009g\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 150.83\u2009\u00b1\u200911.24\u2009mg gallic acid equivalent\u2009g\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. Antimicrobial tests show notable activity against\n                    <jats:italic>Chromobacterium violaceum<\/jats:italic>\n                    (minimal inhibitory concentration (MIC)\u2009&lt;\u20095\u2009mg\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Antibiofilm effects are significant with 82.52% and 81.32% inhibition at MIC and sub\u2010MIC levels. The extract also inhibits violacein production in the\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    CV12472 strain (90.76% at MIC). Gas chromatography\u2010mass spectrometry analysis identifies seven major compounds, including allyl isothiocyanate and levoglucosan. Molecular docking reveals levoglucosan as the most potent CviR receptor binder (\u22126.8\u2009kcal\u2009mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). These interactions suggest possible quorum sensing inhibition via antagonism. Molecular dynamics simulations confirm the stability of the ligand\u2013receptor complexes, highlighting guanosine and levoglucosan as promising leads for drug development.\n                  <\/jats:p>","DOI":"10.1002\/open.202500236","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:37:40Z","timestamp":1752572260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Arenaria serpyllifolia<\/i>\n                    as a Natural Antiviolaceum Agent: Phytochemical, Biological, and Molecular Approaches"],"prefix":"10.1002","volume":"14","author":[{"given":"Meryem Burcu","family":"K\u00fclahc\u0131","sequence":"first","affiliation":[{"name":"Faculty of Science Department of Biology Gazi University  06500 Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00fcl","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Biology Gazi University  06500 Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Incilay","family":"Toruno\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Biochemistry Necmettin Erbakan University  42090 Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekeriya","family":"D\u00fczg\u00fcn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Biology Giresun University  28100 Giresun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Durmaz","sequence":"additional","affiliation":[{"name":"Ali Nihat G\u00f6kyi\u011fit Botanical Garden Application and Research Center Artvin \u00c7oruh University  08000 Artvin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0183","authenticated-orcid":false,"given":"Erdi Can","family":"Aytar","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Department of Horticulture Usak University  64200 U\u015fak T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"156","volume":"15","author":"dos Santos J. 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