{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:56:48Z","timestamp":1791982608302,"version":"4.4.0"},"reference-count":70,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    In this study, a series of novel benzimidazothiazole\u2013thiazole hybrids is synthesized via the condensation of 2\u2010(1\u2010(3\u2010methylbenzoimidazo[2,1\u2010b]thiazol\u20102\u2010yl)ethylidene)hydrazine\u20101\u2010carbothioamide with various hydrazonoyl halides and \u03b1\u2010halo compounds. Structural elucidation is confirmed by infrared, nuclear magnetic resonance (NMR), mass spectrometry (MS), and elemental analysis. The anticancer activities of the synthesized compounds are assessed against the HCT\u2010116 colon carcinoma cell line using the MTT assay, where compound\n                    <jats:bold>16b<\/jats:bold>\n                    exhibits the strongest cytotoxic effect (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 4.31 \u00b1 1.07\u2009\u03bcM), outperforming the reference drug doxorubicin (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 7.05 \u00b1 0.49\u2009\u03bcM). Compounds\n                    <jats:bold>16a<\/jats:bold>\n                    ,\n                    <jats:bold>12<\/jats:bold>\n                    , and\n                    <jats:bold>10a<\/jats:bold>\n                    also demonstrate potent activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    &lt; 7.1\u2009\u03bcM). Molecular docking studies against the colon cancer protein target 6MTU reveal that these active compounds, especially\n                    <jats:bold>16b<\/jats:bold>\n                    , form stable interactions through key hydrogen bonding and \u03c0\u2010type interactions, with binding energies more favorable than doxorubicin. Additionally, in silico ADMET analysis highlights excellent absorption (up to 100%), moderate distribution, CYP450 interactions, and no predicted skin sensitization toxicity. These results position compound\n                    <jats:bold>16b<\/jats:bold>\n                    as a promising lead molecule for further preclinical development as a targeted colon cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/open.202500288","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T07:11:13Z","timestamp":1752217873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole\u2013Thiazole Hybrids as Potent Colon Cancer Inhibitors"],"prefix":"10.1002","volume":"14","author":[{"given":"Bader","family":"Huwaimel","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy University of Ha'il  Ha'il 55473 Saudi Arabia"},{"name":"Medical and Diagnostic Research Center University of Ha'il  Ha'il 55473 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr S.","family":"Abouzied","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy University of Ha'il  Ha'il 55473 Saudi Arabia"},{"name":"Medical and Diagnostic Research Center University of Ha'il  Ha'il 55473 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-9202","authenticated-orcid":false,"given":"Magdi E. A.","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Imam Mohammed Ibn Saud Islamic University (IMSIU)  Riyadh 11623 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulwahab","family":"Alamri","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy University of Ha'il  Ha'il 55211 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basant","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Zagazig University  Zagazig 44519 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Alqarni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy University of Ha'il  Ha'il 55473 Saudi Arabia"},{"name":"Medical and Diagnostic Research Center University of Ha'il  Ha'il 55473 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-2837","authenticated-orcid":false,"given":"Sobhi M.","family":"Gomha","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Islamic University of Madinah  Madinah 42351 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"492","volume":"9","author":"Mohammed T. 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