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As environmentally friendly, adjustable, and biocompatible alternatives to traditional organic solvents and ionic liquids, DES possess distinctive physicochemical characteristics\u2014such as strong hydrogen\u2010bonding ability, low volatility, and structural flexibility\u2014that make them effective as functional excipients. This review consolidates a contemporary understanding of the formulation and performance of polymeric matrices containing DES, highlighting their capacity to alter drug release kinetics, improve solubility, and facilitate dual\u2010function systems like therapeutic DES (THEDES). A comprehensive overview of the various types of DES and polymeric carriers, their methods of integration, associated physicochemical effects, and drug release mechanisms is provided. Furthermore, the outline problems associated with stability, sterilization, and regulatory considerations. In addition, the most prospective future uses of DES\u2013polymer systems is examined in stimuli\u2010responsive systems, 3D\u2010printed scaffolds, and advanced tailored medicine. This article supports the broader polite investigation of polymers and DES in polymeric systems in DDS as a significant step toward safer, more environmentally friendly, high\u2010efficiency pharmaceutical technologies.<\/jats:p>","DOI":"10.1002\/open.202500332","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:39:22Z","timestamp":1755563962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deep Eutectic Solvents in Polymeric Drug Carriers: Insights into Release Behavior and Functional Integration"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1453-9237","authenticated-orcid":false,"given":"Nining","family":"Nining","sequence":"first","affiliation":[{"name":"Doctoral Program in Pharmacy Universitas Padjadjaran  Sumedang 45363 Indonesia"},{"name":"Department of Pharmaceutical Technology Universitas Muhammadiyah Prof. DR. 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