{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:57:19Z","timestamp":1791597439532,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    This study evaluated the sedative activity of abietic acid (AA) through a thiopental sodium (TS)\u2010induced sleep model in mice. AA (5, 10, and 20\u2009mg\/kg) and diazepam (DZP) (2\u2009mg\/kg) were provided, followed by TS (20\u2009mg\/kg) after 30\u2009min to induce sleep. Sleep latency and total sleeping time were documented over a 4 h period. Additionally, molecular docking studies were conducted to examine the interactions of AA with GABA\n                    <jats:sub>A<\/jats:sub>\n                    (Protein Data Bank: 6X3X) receptors, which hold two subunits of \u03b11 and \u03b22, alongside pharmacokinetic and toxicity assessments. The results indicated that AA significantly (\n                    <jats:italic>p\u2009<\/jats:italic>\n                    &lt;\u20090.05) provided the fast onset of sleeping and extended sleeping time in a dose\u2010dependent manner. The combination of AA (20 mg\/kg) with DZP further enhanced sedation, yielding a prolonged sleep duration and a reduced sleep latency, indicating a synergistic effect. In addition, in silico analysis expressed that AA exhibited a strong binding affinity for GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors (\u20137.9\u2009kcal\/mol), comparable to DZP (\u20138.4\u2009kcal\/mol). Furthermore, AA demonstrated favorable pharmacokinetic properties and drug\u2010likeness. Overall, these findings suggest that AA possesses potent sedative effects, likely mediated through interactions with the GABAergic system, warranting further investigation for its therapeutic potential in sleep disorders.\n                  <\/jats:p>","DOI":"10.1002\/open.202500397","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:29:29Z","timestamp":1763965769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System"],"prefix":"10.1002","volume":"15","author":[{"given":"Meher","family":"Afroz","sequence":"first","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2360-0735","authenticated-orcid":false,"given":"Rubel","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst Muslima","family":"Khatun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokammel Hossain","family":"Tito","sequence":"additional","affiliation":[{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd  Gopalganj Bangladesh"},{"name":"Department of Medicine Gazipur Agricultural University  Gazipur Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Shadin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Chakma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Asiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences College of Applied Medical Sciences King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal H.","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology Faculty of Applied Medical Sciences University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah H.","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Faculty of Medicine University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9720","authenticated-orcid":false,"given":"Md Shimul","family":"Bhuia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd  Gopalganj Bangladesh"},{"name":"Pharmacy Discipline Khulna University  Khulna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300906"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.1471"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1392203"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43994-024-00140-2"},{"key":"e_1_2_11_6_1","first-page":"2515690X2211146","article-title":"A Review of African Medicinal Plants and Functional Foods for the Management of Alzheimer's Disease\u2010Related Phenotypes, Treatment of HSV\u20101 Infection and\/or Improvement of Gut Microbiota","volume":"27","author":"Tettevi E. J.","year":"2022","journal-title":"Journal of Evidence\u2010Based Complementary & Alternative Medicine"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.109298"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.07.014"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.26"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60750-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S134864"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0372"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22250"},{"key":"e_1_2_11_14_1","first-page":"65","article-title":"Psychiatric Emergencies (part II): Psychiatric Disorders Coexisting with Organic Diseases","volume":"17","author":"Testa A.","year":"2013","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10061206"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202403725"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0463-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.94.026"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115800"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666151215104302"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqaa027"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43141-021-00224-0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-024-02261-z"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266296096240408032738"},{"key":"e_1_2_11_25_1","volume-title":"Naturally Occurring Benzodiazepines, Endozepines, and Their Receptors","author":"Kitzen J. M.","year":"2021"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-3-361"},{"key":"e_1_2_11_27_1","first-page":"401","volume-title":"Sedation and Analgesia for the Pediatric Intensivist: A Clinical Guide","author":"Mathur M.","year":"2021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57173-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2414"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-023-03520-3"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176289"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12244189"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8139"},{"key":"e_1_2_11_34_1","first-page":"273","volume-title":"Cole in Progress in Medicinal Chemistry","author":"Stanzione F.","year":"2021"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2413039"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18071054"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12448"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipha.2024.03.001"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.3c00352"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666211115124149"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-025-00639-7"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101014"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/13233.6287"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2021.01.011"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111055398"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.017"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2025.03.004"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-024-01128-6"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88599-5"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55040110"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40160-2"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2014.11.009"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501240"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/qua.27438"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.02.008"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-020-04385-6"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.10.005"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00539-w"},{"key":"e_1_2_11_59_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.31083\/ph.2012.1726","article-title":"Comparison of Prediction Models for Blood Brain Barrier Permeability and Analysis of the Molecular Descriptors","volume":"67","author":"Wu Z.\u2010Y.","year":"2012","journal-title":"Die Pharmazie"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1504\/IJCBDD.2013.052195"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.148776"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv038"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2018.08.018"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.15547\/bjvm.983"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.4314\/sokjvs.v16i4.8"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00044"}],"container-title":["ChemistryOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.202500397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/open.202500397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.202500397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:27:30Z","timestamp":1778826450000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/open.202500397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/open.202500397"],"URL":"https:\/\/doi.org\/10.1002\/open.202500397","archive":["Portico"],"relation":{},"ISSN":["2191-1363","2191-1363"],"issn-type":[{"value":"2191-1363","type":"print"},{"value":"2191-1363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,23]]},"assertion":[{"value":"2025-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500397"}}