{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:35:23Z","timestamp":1793046923526,"version":"4.5.0"},"reference-count":86,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002583","name":"GNU","doi-asserted-by":"publisher","award":["Research Resurgence under the Glocal University 30 Project at Gyeongsang National University in 2024"],"award-info":[{"award-number":["Research Resurgence under the Glocal University 30 Project at Gyeongsang National University in 2024"]}],"id":[{"id":"10.13039\/501100002583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:italic>Artemisia fukudo<\/jats:italic>\n                    Makino is a biennial halophyte from the Asteraceae family, known for its tolerance to high\u2010salinity soils. Based on the excellent activity of\n                    <jats:italic>A. fukudo<\/jats:italic>\n                    extract in regulating the 5\u03b1\u2010reductase type 2 (5\u03b1R2) enzyme, this study aimed to investigate the phytochemical properties and pharmaceutical potential of\n                    <jats:italic>A. fukudo<\/jats:italic>\n                    for treating benign prostatic hyperplasia (BPH) and alopecia. Eight compounds including sesquiterpenes (\n                    <jats:bold>1<\/jats:bold>\n                    <jats:bold>\u20134<\/jats:bold>\n                    ), coumarin (\n                    <jats:bold>5<\/jats:bold>\n                    ), and flavonoids (\n                    <jats:bold>6<\/jats:bold>\n                    <jats:bold>\u20138<\/jats:bold>\n                    ) were isolated from 90% MeOH fraction of\n                    <jats:italic>A. fukudo<\/jats:italic>\n                    , and their structures were determined using NMR and MS experiments. Among the isolated compounds, compounds\n                    <jats:bold>5\u20137<\/jats:bold>\n                    were detected in HPLC\u2010DAD, and contents of compounds\n                    <jats:bold>5<\/jats:bold>\n                    <jats:bold>\u20138<\/jats:bold>\n                    were successfully quantified using ESI\u2010MS. It was found that 90% MeOH fraction of\n                    <jats:italic>A. fukudo<\/jats:italic>\n                    contained scopoletin (\n                    <jats:bold>5<\/jats:bold>\n                    ), jaceosidin (\n                    <jats:bold>6<\/jats:bold>\n                    ), eupatilin (\n                    <jats:bold>7<\/jats:bold>\n                    ), and jaceidin (\n                    <jats:bold>8<\/jats:bold>\n                    ) at the concentration of 1.44, 35.71, 6.44, and 11.19\u2009mg\/g, respectively. Compound\n                    <jats:bold>8<\/jats:bold>\n                    effectively inhibited the expressions of BPH\u2010related proteins, AR, PCNA, PSA, and 5\u03b1R2 in LNCaP and RWPE\u20101 cells. Meanwhile, compound\n                    <jats:bold>7<\/jats:bold>\n                    exhibited potent activity in regulating Wnt\/\u03b2\u2010catenin signaling and induced the expression of VEGF and IGF\u20101 in HaCaT and HUVECs. These findings suggest that\n                    <jats:italic>A. fukudo<\/jats:italic>\n                    and its bioactive constituents represent novel natural substances for treatment or improvement of BPH and alopecia.\n                  <\/jats:p>","DOI":"10.1002\/open.202500481","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:53:20Z","timestamp":1773024800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemical Profiling of the Halophyte\n                    <i>Artemisia fukudo<\/i>\n                    Makino and Its In Vitro Effects on Androgen\u2010Related Pathways Associated With Benign Prostatic Hyperplasia and Alopecia"],"prefix":"10.1002","volume":"15","author":[{"given":"Yun Na","family":"Kim","sequence":"first","affiliation":[{"name":"Agri\u2010Food Bio Convergence Institute Gyeongsang National University  Jinju\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Agri\u2010Food Bio Convergence Institute Gyeongsang National University  Jinju\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Green Bio Science (BK21) Gyeongsang National University  Jinju\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Agri\u2010Food Bio Convergence Institute Gyeongsang National University  Jinju\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Health Research Division of Gyeongnam Bio\u2010Environmental Research Korea Institute of Toxicology (KIT)  Jinju\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hyun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Health Research Division of Gyeongnam Bio\u2010Environmental Research Korea Institute of Toxicology (KIT)  Jinju\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hye","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Pusan National University  Busan\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong\u2010Oh","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oceanography Kunsan National University  Gunsan\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-632X","authenticated-orcid":false,"given":"Jung\u2010Rae","family":"Rho","sequence":"additional","affiliation":[{"name":"Department of Oceanography Kunsan National University  Gunsan\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-820X","authenticated-orcid":false,"given":"Eun Ju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Agri\u2010Food Bio Convergence Institute Gyeongsang National University  Jinju\u2010Si Republic of Korea"},{"name":"Department of Green Bio Science (BK21) Gyeongsang National University  Jinju\u2010Si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2008.02531.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/07388551.2011.630647"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.02.031"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcu267"},{"key":"e_1_2_10_6_1","unstructured":"M.Boscaiu 63 2017 59\u201361 An. 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