{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:52:17Z","timestamp":1781855537470,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    A series of novel furochromen derivatives, namely (\n                    <jats:italic>2E<\/jats:italic>\n                    )\u20101\u2010(6\u2010hydroxy\u20104,7\u2010dimethoxy\u20101\u2010benzofuran\u20105\u2010yl)\u20103\u2010arylprop\u20102\u2010en\u20101\u2010ones\n                    <jats:bold>4a\u2013c<\/jats:bold>\n                    , were synthesized via the Knoevenagel condensation of 6\u2010hydroxy\u20104,7\u2010dimethoxybenzofuran\u20105\u2010ylethanone\n                    <jats:bold>2<\/jats:bold>\n                    with various aromatic aldehydes. Molecular structures were fully established using ultraviolet\u2013visible spectroscopy (UV\u2013vis), fourier transform infrared (FTIR), Mass Spectrometry, and nuclear magnetic resonance (NMR)\u00a0techniques. The photophysical characteristics of the compounds were systematically studied in various solvents at 298\u2009K., revealing significant solvatochromic behavior and fluorescence emission, suggesting their potential as fluorescent probes for biological imaging. In addition, quantum chemical calculations discrete fourier transform (DFT)\/B3LYP) were performed to determine highest occupied molecular orbital\u2010lowest unoccupied molecular orbital (HOMO\u2013LUMO) energies and dipole moments in both ground and excited states. To assess their biological relevance, the synthesized compounds were tested for their antiproliferative activity against human cancer cell lines A549 (lung), HepG2 (liver), and HCT\u2010116 (colon), using real\u2010time cell impedance spectroscopy. Among the tested molecules, compound 4c showed the most potent cytotoxic effect, with complete inhibition of cell viability in A549 and HepG2 cells and an IC50 of 4.6 \u00b5M against A549. These findings highlight the dual potential of furochromene derivatives as both photophysical tools and promising anticancer candidates.\n                  <\/jats:p>","DOI":"10.1002\/open.70213","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:37:22Z","timestamp":1779421042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Photophysical Characterization, and Anticancer Evaluation of Novel Furochromene Derivatives"],"prefix":"10.1002","volume":"15","author":[{"given":"Amal","family":"Rabahi","sequence":"first","affiliation":[{"name":"Applied Organic Chemistry Laboratory Faculty of Chemistry University of Sciences and Technology Houari Boumediene  Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha Mounir","family":"Bouhenna","sequence":"additional","affiliation":[{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico\u2010chimiques (CRAPC)  Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnia","family":"Abdeldjebar","sequence":"additional","affiliation":[{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico\u2010chimiques (CRAPC)  Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massinissa","family":"Baymout","sequence":"additional","affiliation":[{"name":"Applied Organic Chemistry Laboratory Faculty of Chemistry University of Sciences and Technology Houari Boumediene  Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Makhloufi\u2010Chebli","sequence":"additional","affiliation":[{"name":"Laboratory of Physics and Chemistry of Materials (LPCM) Department of Chemistry Faculty of Sciences Mouloud Mammeri University  Tizi\u2010Ouzou Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Luyten","sequence":"additional","affiliation":[{"name":"Department of Biology Animal Physiology and Neurobiology Section  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5980-391X","authenticated-orcid":false,"given":"Hamdi","family":"Bendif","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-7836","authenticated-orcid":false,"given":"Anis Ahmad","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3493-6451","authenticated-orcid":false,"given":"Walid","family":"Elfalleh","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105475"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2021.109970"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.143712"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.144184"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA16228E"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3508"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1068162022040082"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2026.130562"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.141387"},{"key":"e_1_2_10_12_1","first-page":"868","article-title":"Structure\u2010Activity Relationships and Molecular Docking Studies of Chromene and Chromene Based Azo Chromophores: A Novel Series of Potent Antimicrobial and Anticancer Agents","volume":"16","author":"Afifi T. H.","year":"2017","journal-title":"EXCLI Journal"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1476503"},{"key":"e_1_2_10_14_1","first-page":"110","article-title":"O.M.Salama. HPLC Simultaneous Determination of Khellin and Visnagin in Ammi Visnaga L. Fruits","volume":"11","author":"Bishr M. M.","year":"2016","journal-title":"IOSR Journal of Pharmacy and Biological Sciences"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.11.011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22030479"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.09.011"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959426"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.08.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074917"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.719504"},{"key":"e_1_2_10_22_1","first-page":"1","volume-title":"Progress in Photochemistry and Photophysics","author":"Kawski A.","year":"1992"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.06.009"},{"key":"e_1_2_10_24_1","volume-title":"Computer\u2010Aided Molecular Design: Theory and Applications","author":"Doucet J.\u2010P.","year":"1996"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520618666180130102259"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2011.05.102"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2007.04.016"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2614(83)87086-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2006.04.036"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.10.142"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.218.4574.747"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2009.11.023"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.5562\/cca2240"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.12.058"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.5562\/cca2240"},{"key":"e_1_2_10_36_1","first-page":"1853","article-title":"Synthesis of New Quinoxaline, Pyrimidine, and Pyrazole Furochromone Derivatives as Cytotoxic Agents","volume":"26","author":"Abdel\u2010Aziz M.","year":"2017","journal-title":"Medicinal Chemistry Research"}],"container-title":["ChemistryOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.70213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/open.70213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.70213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:14:27Z","timestamp":1781853267000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/open.70213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/open.70213"],"URL":"https:\/\/doi.org\/10.1002\/open.70213","archive":["Portico"],"relation":{},"ISSN":["2191-1363","2191-1363"],"issn-type":[{"value":"2191-1363","type":"print"},{"value":"2191-1363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70213"}}