{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:13:35Z","timestamp":1778850815122,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    This study was undertaken to examine, for the first time, the antioxidant and enzyme inhibitory properties of several extracts obtained from the aerial parts of\n                    <jats:italic>Teucrium scordium<\/jats:italic>\n                    subsp.\n                    <jats:italic>scordioides<\/jats:italic>\n                    (Schreb.) Arcang (family: Lamiaceae). Among the extracts, the EtOH extract contained the highest total phenolic (89.96\u2009mg\u2009 GAE\/g) and flavonoid (45.74\u2009mg\u2009 RE\/g) contents. Phenylethanoid glycosides were predominant, particularly in the ethanol and aqueous extracts, and teucroside\/forsythoside B and verbascoside\/forsythoside A were tentatively identified as the major compounds. EtOH and 70% EtOH extracts showed comparable (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05) anti\u2010DPPH activity (201.89 and 188.52\u2009mg\u2009 TE\/g), Cu\n                    <jats:sup>++<\/jats:sup>\n                    (562.81 and 547.88\u2009mg\u2009 TE\/g), and Fe\n                    <jats:sup>+++<\/jats:sup>\n                    (329.13 and 320.08\u2009mg\u2009 TE\/g) reducing capacities. The EtOH extract showed the best antityrosinase activity (72.00\u2009mg\u2009 \u2009KAE\/g). The EtOAc extract inhibited human carbonic anhydrase (CA) isoenzymes I and CAII (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200926.86 and 65.37\u2009\u03bcg\/mL, respectively). Complementary in silico analyses of the major phenylethanoid and flavonoid glycosides supported their possible multitarget interaction patterns and identified the Forsythoside A\u2013BChE complex as a computationally favorable model for future experimental validation. Overall, these findings indicate that\n                    <jats:italic>T. scordium<\/jats:italic>\n                    subsp.\n                    <jats:italic>scordioides<\/jats:italic>\n                    may represent a natural source of antioxidants and enzyme inhibitors for use in different health\u2010promoting formulations.\n                  <\/jats:p>","DOI":"10.1002\/open.70216","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:55:28Z","timestamp":1777445728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Constituents and Biological Potentials of\n                    <i>Teucrium scordium<\/i>\n                    subsp.\n                    <i>scordioides<\/i>\n                    Extracts: In Vitro Experimental and In Silico Perspectives"],"prefix":"10.1002","volume":"15","author":[{"given":"Bengusu Hacer","family":"Akgul","sequence":"first","affiliation":[{"name":"Department of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-3526","authenticated-orcid":false,"given":"Sakina","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Botany Faculty of Science University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-6553","authenticated-orcid":false,"given":"Mehmet Veysi","family":"Cetiz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine Harran University  Sanliurfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0268-7497","authenticated-orcid":false,"given":"Enver","family":"Saka","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0180-5172","authenticated-orcid":false,"given":"Eulogio J.","family":"Llorent\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Physical and Analytical Chemistry Faculty of Experimental Sciences University of Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"G\u00f3mez\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Physical and Analytical Chemistry Faculty of Experimental Sciences University of Ja\u00e9n  Ja\u00e9n 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