{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:52:12Z","timestamp":1781855532320,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    This study describes the fabrication and examination of binuclear copper(II) phenylacetate (PAA) complex with metronidazole (mnz), formulated as [Cu\n                    <jats:sub>2<\/jats:sub>\n                    (\u03bc\u2010PAA)\n                    <jats:sub>4<\/jats:sub>\n                    (mnz)\n                    <jats:sub>2<\/jats:sub>\n                    ](mnz)\n                    <jats:sub>2<\/jats:sub>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)\n                    <jats:sub>2<\/jats:sub>\n                    (\n                    <jats:bold>1<\/jats:bold>\n                    ). The complex was synthesized at room temperature and the product was characterized via FTIR, UV\u2013Vis, and PXRD. The single\u2010crystal X\u2010ray diffraction of complex\n                    <jats:bold>1<\/jats:bold>\n                    reveals that it crystallizes in the triclinic space group P\u20101. The SCXRD illustrated that complex\n                    <jats:bold>1<\/jats:bold>\n                    adopts a bidentate bridging mode with an almost ideal square\u2010pyramidal geometry (\n                    <jats:italic>\u03c4<\/jats:italic>\n                    <jats:sub>5<\/jats:sub>\n                    descriptor). Complex\n                    <jats:bold>1<\/jats:bold>\n                    is stabilized by extended hydrogen\u2010bonding networks, as confirmed by Hirshfeld surface analysis and 2D fingerprint plots. Quantitative analysis demonstrated that H\u00b7\u00b7\u00b7H interactions dominate the crystal packing (49.6% in\n                    <jats:bold>1<\/jats:bold>\n                    ), indicating that van der Waals forces are the major contributors to solid\u2010state stability. DFT calculations confirmed the structural stability and electronic features of the binuclear copper complex. FMO analysis revealed a narrow HOMO\u2013LUMO energy gap (1.39\u2009eV), indicating enhanced electronic responsiveness and chemical reactivity. RDG analysis indicated that molecular stability arises from a balance of coordination\u2010driven attractive interactions, weak dispersive forces, and localized steric effects. Furthermore, docking study against the SARS\u2010CoV\u20102 main protease showed favorable binding affinity (\u22127.97\u2009kcal\/mol), suggesting potential biological relevance of the complex as a metal\u2010based bioactive scaffold.\n                  <\/jats:p>","DOI":"10.1002\/open.70231","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:18:42Z","timestamp":1779283122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Crystal Structure, Hirshfeld Surface, RDG, ELF, LOL, DFT, and Molecular Docking Studies of a Binuclear Copper(II) Carboxylate Complex"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-0766","authenticated-orcid":false,"given":"Abiodun Atoyebi","family":"Ajibola","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences Thomas Adewumi University  Oko\u2010Irese Kwara State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7868-9085","authenticated-orcid":false,"given":"Mehran","family":"Feizi\u2010Dehnayebi","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences Faculty of Pharmacy Suleyman Demirel University  Isparta T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-9425","authenticated-orcid":false,"given":"Senem","family":"Akkoc","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences Faculty of Pharmacy Suleyman Demirel University  Isparta T\u00fcrkiye"},{"name":"Faculty of Engineering and Natural Sciences Bahcesehir University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7797-0262","authenticated-orcid":false,"given":"Les\u0142aw","family":"Siero\u0144","sequence":"additional","affiliation":[{"name":"Institute of General and Ecological Chemistry Lodz University of Technology  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-0748","authenticated-orcid":false,"given":"Waldemar","family":"Maniukiewicz","sequence":"additional","affiliation":[{"name":"Institute of General and Ecological Chemistry Lodz University of Technology  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5QI01178G"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-02872-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-025-01570-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics13040109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c04627"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00290"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/eraf092"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2012.730145"},{"key":"e_1_2_10_10_1","article-title":"Novel Structures of Zn (II) Biometal Cation with the Biologically Active Substituted Acetic Acid and Nitrogen Donor Ligands: Synthesis, Spectral, Phosphate Diester Catalytic Hydrolysis and Anti\u2010Microbial Studies","volume":"31","author":"Ali H. 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