{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:52:12Z","timestamp":1781855532269,"version":"3.54.5"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistryOpen"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Silver nanoparticles were synthesized using\n                    <jats:italic>Acacia<\/jats:italic>\n                    <jats:italic>karroo aqueous<\/jats:italic>\n                    leaves extract for the first time, as evidenced by a characteristic UV\u2013Vis absorption peak at 424\u2009nm. Spherical morphologies were observed using transmission electron microscopy (TEM) and scanning electron microscopy (SEM), with mean diameters determined to be 33\u2009nm. XRD analysis validated the crystalline nature of the nanoparticles, with characteristic peaks at 2\n                    <jats:italic>\u03b8<\/jats:italic>\n                    values of 38.19\u00b0, 44.34\u00b0, 46.21\u00b0, 64.35\u00b0, 77.54\u00b0, and 81.39\u00b0 corresponding to the (111), (200), (211), (220), (311), and (222) planes of face\u2010centered cubic silver. Synthesized AgNPs demonstrated moderate anti\u2010\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and antibacterial properties against the tested strains. Overall, AgNPs\u2010treated\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    showed higher levels of cell leakage, protein content, and malondialdehyde concentrations than untreated cells. Molecular docking studies demonstrated strong interactions between silver and microbial proteins, with the highest binding affinity observed for protein 5NG5, followed by 5BNM and 3HUM.\n                  <\/jats:p>","DOI":"10.1002\/open.70237","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:04:11Z","timestamp":1780383851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Antimicrobial Activity, Membrane Integrity, and Oxidative Stress of Green Synthesized Silver Nanoparticles: In Vitro and Molecular Docking Studies"],"prefix":"10.1002","volume":"15","author":[{"given":"Sarra","family":"Sebti","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology Higher National School of Biotechnology Taoufik Khaznadar  Ali Mendjeli Constantine Algeria"},{"name":"Biotechnology Research Center (CRBt)  Ali Mendjeli Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-8461","authenticated-orcid":false,"given":"Badra","family":"Barhouchi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center (CRSP)  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Meskaldji","sequence":"additional","affiliation":[{"name":"\u00c9cole Normale Sup\u00e9rieure de l\u2019Enseignement Technologique (ENSET)  Skikda Algeria"},{"name":"Laboratoire de Physique Math\u00e9matique et Subatomique (LPMPS) Universit\u00e9 des fr\u00e8res Mentouri  Constantine 1 Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroun","family":"Houicha","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanical Engineering University Mohamed Khider of Biskra  Biskra Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyup","family":"Bagci","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Firat University  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5980-391X","authenticated-orcid":false,"given":"Hamdi","family":"Bendif","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3493-6451","authenticated-orcid":false,"given":"Walid","family":"Elfalleh","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prenap.2025.100142"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139141"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apt.2017.09.028"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA07519F"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hybadv.2024.100220"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2011.01.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2017.03.021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.04.266"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl301934w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.02.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nxnano.2024.100089"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01648\u201024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2021.102457"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colcom.2021.100449"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102697(76)90527\u20103"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274\u2010018\u20102500\u20101"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24905"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00053"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.00822\u201009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm051197e"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010136"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1013030"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4482"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010021\u201000597\u2010z"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051038"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107007\u20109\u201071"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.11.075"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S53546"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2013.11.019"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/17518253.2024.2444679"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10020202"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.01.003"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449\u2010008\u20100224\u20106"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.01.019"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1088\/2043\u20106254\/aaabb2"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145817"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08459"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fpc.2025.01.002"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2024.100867"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201045038\u2010x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117026"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wroa.2024.100296"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e40131"},{"issue":"1","key":"e_1_2_10_45_1","first-page":"1","article-title":"Green Synthesis and Characterization of Silver Nanoparticles from Euphorbia Kamerunica Latex, and the Synergistic Antimicrobial Effects of Their Functionalization with Co\u2010Amoxiclav","volume":"12","author":"Faboyede A. O.","year":"2024","journal-title":"Covenant Journal of Physical and Life Sciences"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1515\/gps\u20102023\u20100080"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121959"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.11.015"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA07060G"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microb.2025.100573"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40486\u2010024\u201000218\u2010w"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00155"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2014.04.013"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2018.359.368"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.125059"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S150648"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010023\u201003835\u20101"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S191340"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1293363"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020369"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e35642"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2269-7_19"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b02374"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726\u2010019\u201002728\u2010z"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40203\u2010017\u20100031\u20103"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201024818\u2010x"}],"container-title":["ChemistryOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.70237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/open.70237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/open.70237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:14:17Z","timestamp":1781853257000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/open.70237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/open.70237"],"URL":"https:\/\/doi.org\/10.1002\/open.70237","archive":["Portico"],"relation":{},"ISSN":["2191-1363","2191-1363"],"issn-type":[{"value":"2191-1363","type":"print"},{"value":"2191-1363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70237"}}